Beta-thalassemia is an inherited blood disorder. It results from the impaired production of -globin chains, leading to a relative excess of alpha-globin chains. Clinical severity separates this disease into three main subtypes: - thalassemia major, -thalassemia intermedia and -thalassemia minor, the...
Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia. To characterize systematically the mutations which produce beta-thalassemia in Asian Indians, we first determined the DNA polymorphism haplotype in the bet... Orkin,S.,H.,... - 《Proceedings of the National Ac...
In case of one mutated gene, sufferers may have mild symptoms. This type of the disease is known as Beta- Thalassemia minor or called a Beta-Thalassemia trait. Acquiring two mutated genes may lead patients to suffer from symptoms that range from moderate to severe in nature. The form of t...
Hemoglobin sickle beta thalassemia Rare types are: Hemoglobin SD Hemoglobin SE Hemoglobin SO Sickle Cell Disease Diagnosis A blood test can check for the defective form of hemoglobin found in people with sickle cell disease. This test is available for newborns, older children, and adults. In the ...
of thalassemia, there is misproduction in alpha or beta chains. “In cases where only one of the parents is a carrier of thalassemia, you may develop the disease called thalassemia minor. In such cases, no symptoms as such will be seen. However, some people might experience minor symptoms....
As thalassemia gene mutation prevalents in Fujian, the screening of thalassemia genotypes for childbearing age woman has great significance for raising population quality. 显示全文DOI: 10.7534/j.issn.1009-2137.2017.02.035 关键词: Alpha thalassemia; Beta thalassemia; China; Female; Genetics; Genotype;...
Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and con
Thalassemia gene carriers can be diagnosed by molecular biology in order to conduct effective guidance for fertility. Designs and methods For --SEA and --THAI of α-thalassemia and HPFH-SEA and DBT of β-thalassemia, we design the fGap-PCR primer; for αCSα, αQSα and αWSα, we ...
Any process that can disrupt the normal life span of a red blood cell may cause anemia. The normal life span of a red blood cell is typically around 120 days.Red blood cellsare made in the bone marrow. Anemia is caused essentially through two basic pathways. Anemia is caused by either:...
The synthesis of fetal hemoglobin types in red blood cells and in BFU-E derived colonies from peripheral blood of patients with sickle cell anemia, beta烯- and delta-thalassemia, various forms of hereditary persistent of fetal hemoglobin in normal adults and newborn. Hemo- globin 1979;3:223-...