Amyloid beta-Protein PrecursorProtein PrecursorsOligonucleotide ProbesRNA, MessengerBlotting, NorthernGene Expression RegulationThree types of amyloid protein precursor (APP) mRNA, produced by alternative splicing, were detected by Northern blotting in human brains, both control and Alzheimer's disease. These...
Symptoms of amyloidosis are often subtle. They can also vary greatly depending on where the amyloid protein is collecting in the body. It is important to note that the symptoms described below may be due to a variety of health problems. Only your doctor can make a diagnosis of amyloidosis. ...
An I-123 labelled SAP scan demonstrated a small amount of amyloid confined to the kidneys. She had no overt underlying inflammatory disease, an infectious diseases work up, including blood borne viruses, was negative and serial measurement of serum amyloid A protein showed no significant elevation ...
Differential expression of three types of amyloid β-protein precursor mRNA in the brain and nonneural tissues : ∗S. Tanaka1,2, S. Nakamura1, K. Ueda2, S. Shiojiri3, Y. Takahashi3, N. Kitaguchi3, H. Ito3. 1Department of Neurology, 2Department of Clinical Science and Laboratory ...
《Amyloid-journal of Protein Folding Disorders》Zhao N, Nobue A, Benson MD, Skinner M, Satier F, Sakaki Y. Haplotype analysis of His 58, Ala 60 and Tyr 77 types of fa- milial amyloidotic polyneuropathy. Amyloid 1994;1:75-79.Zhao, N, Aoyama, N, Benson, MD, Skinner, M, Satier, ...
(or beta-amyloid). This protein is derived from a larger molecule calledamyloid precursor protein, which is a normal component of nerve cells. Neurofibrillary tangles are twisted protein fibres located within nerve cells. These fibres consist of a protein, calledtau, that normally occurs inneurons...
Cytokine’s expression is regulated at the transcription level, translation level, and protein synthesis. The expression of cytokines also seems to be regulated differentially, depending on cell type and developmental age. Secretion or release from the producer cells is a regulated process. Once releas...
To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains after parabiosis. For each cell type, we cataloged alterations in gene expression, molecular pathways, transcriptional networks, ligand–receptor interactions and senescence status. Our ...
Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Rece
type 1 diabetes, as well as insulin resistance that is more characteristic of type 2 diabetes. It’s also worth mentioning that amyloid beta protein deposits on the pancreas in patients with type 2 diabetes are similar to the protein deposits that occur in the brain in type 3 diabetes(30)....