progression of renal disease, and all-cause mortality. These new data are leading to a paradigm shift in the current management of T2D, with international guidelines now prioritising SGLT2 inhibitors and/or GLP-1 RAs in certain patient populations. However, clinicians are faced with a large volum...
Association of statin therapy initiation with diabetes progression: a retrospective matched-cohort study JAMA Intern Med, 181 (12) (2021), pp. 1562-1574 CrossrefView in ScopusGoogle Scholar [14] S.M. Liew, P.Y. Lee, N.S. Hanafi, et al. Statins use is associated with poorer glycaemic ...
a better understanding of patient-specific hemodynamics and therapy outcomes can potentially control the progression of the disease and aid in the clinical decision-making process. In this work, a patient-specific geometry of type-B AD is
The test compounds represent potential multi-target ligands to control postprandial hyperglycemia, oxidative stress and/or inflammation all of which are linked to the pathogenesis and progression of T2DM, and its complications. Drugs which could reduce hyperglycemia and concomitantly mitigate oxidative ...
AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4). Biochem Biophys Res Commun. 2003;308:177–83. Article PubMed CAS Google Scholar Yokohama S, Tokusashi Y, Nakamura K, Tamaki Y, Okamoto S, Okada M, Aso K, Hasegawa T, Aoshima M, Miyokawa N, ...
Hypertension significantly hastens the progression of diabetic nephropathy and increases the risk of cardiovascular events or death in patients with diabetes. On the contrary, lowering blood pressure decreases albuminuria in type 2 diabetes [10, 11]. On the other hand, ARBs have a beneficial effect...
Luan J, Shattuck-Brandt R, Haghnegahdar H, Owen JD, Strieter R, Burdick M, Nirodi C, Beauchamp D, Johnson KN, Richmond A: Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression. J Leukoc Biol. 1997, 62 (5): 588-59...
Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 di
In conclusion, lixisenatide reduced progression of UACR specifically in macroalbuminuric patients, but did not affect eGFR.34 In the LEADER trial, the composite kidney outcome was new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine levels, ESKD, or death due to kidney ...
Clin Cancer Res 16: 1520–1531. Article CAS PubMed Google Scholar Iwanaga R, Ohtani K, Hayashi T, Nakamura M . (2001). Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene 20: 2055–2067. Article CAS PubMed ...