Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed key tissues and cell...
Bulk-tissue DNA methylomes represent an average over many different cell types, hampering our understanding of cell-type-specific contributions to disease development. As single-cell methylomics is not scalable to large cohorts of individuals, cost-effec
A systems genetics approach across 100 in-bred strains of mice demonstrated that collagen V is a critical driver of postinjury heart function. We show that collagen V deficiency alters the mechanical properties of scar tissue, and altered reciprocal feedback between matrix and cells induces ...
The input data is a Seurat object that contains a UMAP dimensionality reduction. Users should also specify the tissue organ(s), which can be or more of: Bladder, Blood, Bone_Marrow, Eye, Fat, Heart, Kidney, Large_Intestine, Liver, Lung, Lymph_Node, Mammary, Muscle, Pancreas, Protate, ...
In BM, collagen type XVIII is mainly detected around arteries, according to a spatial single celltranscriptomicdata set of theHSCniche that was recently published[107]together with the referring online tool in which the gene Col18a1 can be searched[236]. Previously it was found that endostatin ...
This knowledge may provide insight into key biological processes such as fibrillo-genesis and tissue remodeling and into diseases such as heart disease and cancer. Here we present a crystallographic determination of the collagen type I supermolecular structure, where the molecular conformation of each ...
As for the backing material for heart blood vessel type tissue culture of this invention, being the backing material for heart blood vessel type tissue culture of tube condition which strengthens the foaming body which consists of the organism absorptive material with the stiffener which consists of...
ACTIV-4 Host Tissue Platform Collaborators eFigure 1. Schematic of the renin-angiotensin system (RAS) and trial agent targets eFigure 2. Distribution of oxygen-free days in TXA-127 trial eFigure 3. Distribution of oxygen-free days in TRV-027 trial eFigure 4. TXA-127 trial WHO COVID-19 ...
where Ni is the neighbor set of ith protein and Nj is the neighbor set of jth protein. In order to identify shared key genes (sKGs), a PPI-network of sDEGs was constructed using the STRING database56. To select the sKGs from the PPI network, we used different topological measures (...
Hundreds of cell types form the vertebrate brain but it is largely unknown how similar cellular repertoires are between or within species or how cell-type diversity evolves. To examine cell-type diversity across and within species, we performed single-ce