It is, therefore, necessary to develop novel therapeutic and prophylactic vaccines against TB. To this end, we developed a novel therapeutic vaccine (HVJ-E/HSP65 DNA+IL-12 DNA) against TB. In this chapter, several types of TB vaccines, including novel prophylactic and therapeutic vaccines that...
These results suggest that the PCR-RFLP analysis is a practical and reliable method of differentiating wild- and vaccine-type CPVs.doi:10.1111/j.1439-0450.1995.tb00754.xT HirasawaK YonoK MikazukiJohn Wiley & Sons, Ltd.Zentralblatt Für Veterinrmedizin.reihe B.journal of Veterinary Medicine...
Tuberculosis (TB) is one of the most widespread infectious diseases worldwide, typically persisting in the body as a latent TB infection (LTBI). Patients with type 2 diabetes have an increased risk of LTBI progressing to active TB. Therefore, this study determined the prevalence and predictors ...
The bacillus Calmette-Guérin (BCG) vaccine is one of the oldest vaccines in the world, developed for tuberculosis (TB) protection and for early stage bladder cancer therapy. BCG is an attenuated version of the virulent Mycobacterium bovis. BCG also shows promise as treatment for numerous inflamma...
2016). The importance of T7SS for mycobacterial pathogenicity and physiology is highlighted by the fact that the attenuation of the current tuberculosis live vaccine Mycobacterium bovis Bacillus Calmette-Guérin can mainly be attributed to an inactivating deletion of ESX-1 (Pym et al. 2002). ...
The elevation of IL-5 levels in the two vaccine groups were significant irrespective of whether the sexes were combined or analyzed separately. Other cytokines (VEGF-A, TNF-α, IL-10, MCP-1, GM-CSF, IL-6, and IL-13) were also impacted, although to a lesser extent and in a sex-...
EC were assessed for the absence of clinical signs and symptoms of leprosy and TB. Staff of leprosy- or TB clinics were excluded. Table 1 Participating study sites and study groups Full size table Leprosy prevalence Dhaka, prevalence: 2.45/10,000, new case detection rate (NCDR): 0.31/10,...
A critical unmet need in the field of gene therapy is the ability to robustly deliver biological cargoes, such as DNA, RNA, protein, or ribonucleoproteins (RNPs), to a broad range of target cell types1. To date, adeno-associated viral (AAV) vectors have achieved some tropism, for example...
This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine for an efficacy study. Methods This randomised, double-bl...
A recombinant vector containing infectious genome of human cytomegalovirus (HCMV) and being useful for the production of reconstituted HCMV virus retaining phenotypic cha