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The present technology comprises methods and RNA constructs for the targeted translation of a polypeptide of interest in a eukaryotic target cell, and to the use thereof in therapeutic clinical applications.Bohlen HeribertHoffmann Bernd
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Of note, there is a large contribution of genes and pathways involved in skeletal and neuronal development and function, leading to joint degeneration and symptomatic outcomes. These included the Extracellular matrix (ECM) niche of a chondrocyte, and OA implicated pathways such as Fibroblast growth ...
In this review, we provide a comprehensive overview on the classification, biogenesis and functions of circRNAs. We also discuss the critical role of circRNAs in eliciting antiviral immunity, providing evidence for the potential implications of circRNAs in antiviral therapies. Keywords: circular RNA, ...
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Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single-chain (type-1) RIPs named sodins were isolated from the seeds (five proteins), edible leaves (one protein) and roots (...
Arginine biosynthesis in Corynebacterium glutamicum consists of eight enzymatic steps, starting with acetylation of glutamate, catalysed by N-acetylglutamate synthase (NAGS). There are different kinds of known NAGSs, for example, “classical” ArgA, bifu
Each isotype is encoded by a distinct gene and multiple heavy chain isoforms can be produced by alternative pathways of RNA processing, such as the secreted Ig and membrane Ig forms of all H chains, or full-length and truncated H chain isoforms, as has been reported for some avian species ...
activitystructural constituent of epidermisstructural constituent of cytoskeletonkeratin filament bindingscaffold protein bindingMHC class II receptor activityMHC class II protein bindingpoly(A) RNA bindingcadherin binding involved in cell-cell adhesionstructural constituent of muscleprot...