Multiple sexually transmitted infections (STIs) have threatened human health for centuries. Most STIs spread not only through sexual (horizontal) transmission but also through mother-to-child (vertical) transmission. In a previous work (Ito et al. 2019),
To determine what stage of phage reproduction was impeded, we investigated the effects of CRISPR-Cas on defined aspects of infection. CRISPR-Cas caused a decrease in the efficiency of centre of infection (ECOI) formation (Fig. 1c), meaning that for ɸTE, only 4 or 1% of infected cells...
The virus in chick embryo cells propagated well, can produce high titer viruses in human cells can not effectively reproduce, no or only low titers of progeny virus, but retained the original strain of vaccinia virus Tiantan similar DNA replication, capacity, viral virulence RNA transcription and ...
Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. Here we identify IFN-υ from the genomic sequence...
ADA was also reported to induce the modification of NC in viruses and thereby prevent reverse transcription of HIV-1 [17]. However, further development of these types of zinc ejector inhibitors has been mostly limited in part due to either a low or lack of target specificity and cellular ...
(IRF-3) ,which coordinately regulate the expression of type-Ⅰinterferon.Viruses can form double-strand RNA duplication intermediates in the process of ... NI Cai-Fei,B Huang - 《Letters in Biotechnology》 被引量: 0发表: 2008年 加载更多来源...
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In 2006, a new lineage of Type 2 PRRSV emerged in Chinese swine herds that were suffering dramatic losses resulting in those viruses being described as 鈥淗ighly Pathogenic PRRSV鈥 (HP-PRRSV). Experimental reproduction of severe disease with HP-PRRSV isolates and virus derived from HP-PRRSV ...
The majority of patients with systemic lupus erythematosus (SLE) have high expression of type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the contribution of type I IFN exposure to these changes is unknown. Here, we s
viruses, fungi, or allergens, and also to determine to what extent each of these responses is preserved in the blood. We demonstrate a unique global transcriptional signature for each of the different diseases against the controls in both lung and blood. The lung transcriptional signatures showed ...