In the pectoralis muscle (PM) of both normal and dystrophic chicken, slow- and fast-type C-proteins were coexpressed in the vast majority of myofibers at neonatal age, but the slow C-protein disappeared, leaving continued expression of only the fast-type C-protein as muscle development ...
Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients’ samples that muscle stem cells/myoblasts exhibit signs of cellular...
Skeletal muscle conveys several of the health-promoting effects of exercise; yet the underlying mechanisms are not fully elucidated. Studying skeletal muscle is challenging due to its different fiber types and the presence of non-muscle cells. This can be circumvented by isolation of single muscle ...
In conclusion, our data suggest that perturbed Ca2+ homeostasis, via activation of ER stress, contributes to muscle degeneration in DM1 muscle cells likely representing a premature senescence phenotype. Keywords: myotonic dystrophy; muscle cells; Ca2+ homeostasis; SERCA; Ryr1; Cav1.1; ER stress 1....
P-type ATPases constitutes one of the largest protein family which transports ions and lipids across cell membranes against a concentration gradient by utilizing energy obtained from ATP hydrolysis. They are found in all forms of life irrespective of plants or animals. Based on the sequence homolog...
Optimal efficiency of these disparate roles in different fibers is achieved by both specific myofibrillar protein composition and a metabolic capacity that is best suited for that composition. Most muscles in mammals contain a mixture of fiber types, but some muscle beds are enriched in particular ...
Identify the type of muscle shown in the picture given below . View Solution Draw well labelled diagrams of various types of muscles found in human body. View Solution Doubtnut is No.1 Study App and Learning App with Instant Video Solutions for NCERT Class 6, Class 7, Class 8, Class 9,...
When mutations exist in the SMN1 gene, an insufficient amount of SMN protein is made, leading to progressive motor neuron loss and subsequent muscle weakness.Genetic testing generally is needed to confirm an SMA diagnosis. All U.S. states and many other countries offer prenatal and/or newborn ...
Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood. Modulatory region 1 (MR1) is a 1-kb regulatory regi
et al. Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. Arthritis Rheum. 60, 1463–1471 (2009). PubMed Google Scholar Banchereau, R. et al. Personalized immunomonitoring uncovers molecular networks that stratify lupus patients. ...