For example, the ancestral brain was probably devoid of cerebellar cell types and oligodendrocytes (myelinating cells); our data suggest that the latter emerged from astrocyte-like evolutionary precursors in the jawed vertebrate lineage. Altogether, our work illuminates the cellular and molecular ...
Metabolic reprogramming in cancer and immune cells occurs to support their increasing energy needs in biological tissues. Here we propose Single Cell Spatially resolved Metabolic (scSpaMet) framework for joint protein-metabolite profiling of single immun
C-protein is a myosin-associated protein of vertebrate striated muscle, and its function and properties have been extensively examined. However, there has been no report of C-protein of fish skeletal muscle so far. C-protein was identified in carp skeletal muscle by immunoassay using antibody aga...
We profiled 134 regions of interest (each 200 μm in diameter) enriched in melanocytes, neighboring keratinocytes, or immune cells. This approach captured distinct expression patterns across cell types and tumor types during melanoma development. Unexpectedly, we discovered that S100A8...
When mutations exist in the SMN1 gene, an insufficient amount of SMN protein is made, leading to progressive motor neuron loss and subsequent muscle weakness.Genetic testing generally is needed to confirm an SMA diagnosis. All U.S. states and many other countries offer prenatal and/or newborn ...
4.2Overview of collagens in BM Currently, there exists no comprehensive overview of collagens expressed in BM. In the 1990s expression of collagens type I, III, IV, V, VI and XIV in the BM was shown on the protein level[63,64,68,211,212]. On the mRNA level,collagen type IIwas add...
Endomorphs have softer bodies with curves. They have a wide waist and hips and large bones, though they may or may not be overweight. Their weight is often in their hips, thighs, and lower abdomen. Endomorphs often have lots of body fat and muscle and tend to gain weight easily. ...
Using a monoclonal antibody, we have detected a high molecular weight muscle protein, co-localized and co-isolating with desmin. Searching a human cDNA database with partial amino acid sequences of the protein, we found a cDNA clone encoding a 1565-amino-acid polypeptide, identified as a mamma...
Namely, glucose was not consumed as rapidly nor as completely by the chicken muscle precursors compared to other cells overall, and there were significant differences in specific consumption rates for several other key nutrients over the first day of culture. Ultimately, our results indicate that no...
1996. Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature 382:452- 455.Currie PD, Ingham PW: Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature 1996, 382:452-455....