The ESX system appeared to be found in several copies in Mycobacteria genomes, five in Mycobacterium tuberculosis, and it is important for survival and virulence. Each ESX system may have different roles in Mycobacteria pathogenesis, such as ESX-1 being important for the translocation of ...
Mycobacterium tuberculosis is a virulent intracellular pathogen that survives in macrophages even in the presence of an intact adaptive immune response. Type I IFNs have been shown to exacerbate tuberculosis in mice and to be associated with disease progression in infected humans. Nevertheless, the mec...
Diagnosis was based on the clinical history of reproductive failure, characteristic microscopic lesions, and recovery of the organism from the placenta, abortus, or infant (McClure et al., 1986; Paul-Murphy et al., 1990). There was poor response to antibiotic therapy. Mycobacterium Tuberculosis an...
Share on Facebook hypersensitivity (redirected fromDelayed Type Hypersensitivity) Thesaurus Medical Acronyms Encyclopedia hy·per·sen·si·tive (hī′pər-sĕn′sĭ-tĭv) adj. 1.Highly or excessively sensitive. 2.Responding excessively to the stimulus of a foreign agent, such as an allergen...
et al. Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen. PLoS Pathog. 4, e6 (2008). PubMed PubMed Central Google Scholar Pandey, A. K. et al. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. ...
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn’s disease-like inflammation, lung fibrosis, and macrophage lipid accumulation in these patients remains enigmatic. The aim of this study i
The UPOINT still requires the tests of the expressed prostatic secretion (EPS) and lower urinary tract pathogen localization (LUTPL), which have little clinical significance. Studies have shown that there is no significant correlation between the severity of symptoms of type-III prostatitis and the...
We conclude that due to the accessibility of biotyping and the lack of commercially available antisera for S. marcescens, the biotype and ribotype together provide reliable markers of strain identity. 展开 关键词: HIV-1 HIV-2 SURVIVAL MYCOBACTERIUM TUBERCULOSIS CD4+ LYMPHOCYTE BETA(2)-MICROGLOBULIN...
Mycobacterium tuberculosisSTAT4GranulomaDelayed-type hypersensitivity (DTHMycobacterium tuberculosis is an intracellular pathogen of tuberculosis and its pathogenicity is related to the ability to escape killing by ingested macrophages and induce delayed-type hypersensitivity (DTH). A major component of the ...
Insights into this matter are of relevance for redrawing the patho-evolution of M. tuberculosis, which might help improving current strategies for prevention, diagnostics and therapy of tuberculosis as well as elucidating the virulence mechanisms employed by this important human pathogen....