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Type I IFNs are implicated in different autoimmune and inflammatory conditions, although their role in each condition varies. Some autoimmune diseases are improved by the biological effects of type I IFNs, whereas others benefit from type I IFN inhibition. Abstract Interferon-α (IFNα) and IFNβ...
Most, if not all, cells in humans and mice express the receptor for type I interferons (IFNs). Therefore, these cytokines have a range of direct and indirect effects on various cell types during infection with viruses, bacteria, parasites and fungi. Type I IFNs are important for host defen...
true if the current Type is in the inheritance hierarchy of the object represented by o, or if the current Type is an interface that o implements. false if neither of these conditions is the case, if o is null, or if the current Type is an open generic type (that is, ContainsGeneric...
cis a generic type parameter, and the current instance represents one of the constraints ofc. crepresents a value type, and the current instance representsNullable<c>(Nullable(Of c)in Visual Basic). falseif none of these conditions are true, or ifcisnull. ...
A procedure is followed to identify these additional constraint formulas and, ultimately, to express via a bound set the conditions under which the choices for inferred types would render each constraint formula true. Incorporation maintains a set of inference variable bounds, ensuring that these ...
If the IsGenericTypeDefinition property returns true, you can call the MakeGenericType method to create new generic types. For a list of the invariant conditions for terms used in generic reflection, see the IsGenericType property remarks. Applies to ProductVersions .NET Core 2.0, Core 2.1, Core ...
of a program--to make sure it remains free software for all its users. When we speak of free software, we are referring to freedom, not price. Our General Public Licenses are designed to make sure that you have the freedom to distribute copies of free software (and charge for them if ...
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and TCR stimulation. Mechanistically these ‘SLE-like’ conditions increase CD8+T cell NAD+ consumption resulting in impaired mitochondrial respiration and reduced cell viability, both of which can be rectified by NAD+ supplementation. Our data suggest that type I IFN exposure contributes to SLE...