An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse: Parsing the Supporting Genetic Data The strain has been used extensively in efforts to elucidate the pathogenesis of type 1 diabetes in humans. Both the mouse model and the human disease ... SP Weisberg,RL Leibel...
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et al. Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories. Nat. Commun. 13, 1514 (2022). Article CAS PubMed PubMed Central Google Scholar Redondo, M. J. et al. A type 1 diabetes genetic risk score predicts progression of ...
This review addresses the current knowledge of overlapping genetic and epigenetic aspects in type 2 DM and CVD, including microRNAs and long non-coding RNAs, whose abnormal regulation has been implicated in both disease conditions, either etiologically or as cause for their progression. Understanding ...
Limit your child's use of table salt. Give your child high-fiber foods. Fiber helps improve blood sugar levels. Fiber also lowers your child's risk for heart disease and other problems diabetes can cause. Examples of high-fiber foods include vegetables, whole-grain bread, and beans such ...
"Now we can implement this kind of classification and say that even if a patient has the 'bad' ABC type, they have the 'good' genetic type, BN2. So, there's a much better chance of chemotherapy curing the disease," said Staudt. ...
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease that affects just 1 in every 20 million people; it is estimated that fewer than 400 children in the world have the disease. HGPS is characterized by accelerated aging, sever
"The soft-clustering method is better for studying complex diseases, in which disease-related genetic sites may regulate not just one gene or process, but several," said Udler. The new algorithm with a computational tool revealed five clusters of genetic variants distinguished by distinct underlying...
Type 1 diabetes (T1D) patients with low genetic risk scores (GRS) may be non-autoimmune or autoimmune mediated by other genetic loci. The T1D-GRS2 provides us an opportunity to look into the genetic architecture of these patients. A total of 18,949 European individuals were included in thi...
types and functional mechanisms of trait-causal and disease-causal genetic variation. Results Building a framework to decode cell type-level and landscape-scale genetic variation of gene regulation Exploring the effect of non-coding variants is complicated by genomic sequences, heterogeneous chromatin ...