In this review, we focus on the role of DNA methylation, a type of epigenetic modification, in the pathogenesis of T2DM.doi:10.1186/s13148-020-00896-4Sanabil Ali Hassan AhmedSuraiya Anjum AnsariEric P. K. Mensah-BrownBright Starling Emerald...
Epigenetic refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and ...
Epigenetic gene regulation in the heterogeneous brain remains challenging to decipher with current strategies. Bulk tissue analysis from pooled subjects reflects the average of cell-type specific changes across cell-types and individuals, which obscures
Epigenetic modification and inheritance in sexual reversal of tongue-sole fish Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa, and in some species, co-occurs with genetic sex determination (... G Zhang - 《Genome Research》 被引量: 87发表: 2013年 Modern...
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance Guo-Hua Li Qiang Qu Jian Qu Journal of Experimental & Clinical Cancer Research(2021) Advertisement Nature Communications (Nat Commun)ISSN2041-1723(online) Sign up for theNature Briefingnewsletter — what matters in scie...
Unlike nucleobase modifications in canonical restriction-modification systems, DNA phosphorothioate (PT) epigenetic modification occurs in the DNA sugar-phosphate backbone when the nonbridging oxygen is replaced by sulfur in a double-stranded (ds) or single-stranded (ss) manner governed by DndABCDE or...
N. De novo prediction of human chromosome structures: epigenetic marking patterns encode genome architecture. Proc. Natl Acad. Sci. USA 114, 12126–12131 (2017). Article PubMed PubMed Central Google Scholar Bianco, S. et al. Polymer physics predicts the effects of structural variants on ...
Our results indicate that XopZ(PXO99) encodes a novel T3 effector and contributes virulence to X. oryzae pv. oryzae strains for bacterial blight of rice. 展开 关键词: Plant histone methyltransferases SET domain demethylases DNA methylation retrotransposon epigenetic modification rice chromatin DOI: ...
both SINE B2 and ERVL-MaLR elements were significantly enriched, with SINE B2 elements being drastically higher in abundance (42%) as compared to the randomly selected CTCF peaks (32%) (Fig.3a). We then examined the epigenetic profiles of repetitive elements with increased CTCF binding uponSet...
Additionally, 3D genome organization further supports hierarchical chromatin disorganization in MAD stem cells, alongside dysregulation of genes involved in epigenetic modification, stem cell fate maintenance, senescence, and geroprotection. Together, these findings suggestmissense mutation is linked to ...