Substance of Crystals in Joints Mark Gout TypeDear Dr. Donohue: I am 79, and live in Florida. My daughter inChicago sends me your column. I'm...By Dr. Paul Donohue
We also discuss the potential role of IL-1β in obesity, Alzheimer’s disease, fatigue, gonadal dysfunction and related disorders such as rheumatoid arthritis and gout. Finally, we address the safety of NLRP3 inhibition and IL-1 antagonists and the prospect of using this therapeutic approach ...
Such endogenous antagonism in form of a dedicated soluble secreted protein appears to be a unique feature of IL-1 cytokine family members and high- lights the extraordinary tight regulation of the biological activity of IL-1. In addition, a second IL-1R chain, the IL-1RII, is both a ...
The episodes of acute arthritis in patients with gout result from which of the following? True or False: Rheumatoid arthritis is a non-inflammatory joint disease. This condition is metabolic in nature, causing a build up of uric acid crystals in t...
The small plaque mutant phenotype may play a role in the maintenance of the persistent infection in MDCK cells. The pv differs from the wt antigenically and in its ability to form deposits of uric acid-like crystals beneath the culture monolayers. 展开 ...
4, 5 Although IL-1 signaling plays pivotal roles in immunity, sterile inflammation and metabolism1, 6, 7, 8 excessive overproduction of IL-1 is highly detrimental and contributes to auto-inflammatory diseases, autoimmune encephalomyelitis, rheumatoid arthritis and gout.4, 9, 10, 11, 12, 13 IL...
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237–241 89. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, ...
In finite games, understanding the structure and complexity of the set of equilibria is a longstanding problem, both from a practical and theoretical standpoint. Identifying invariances in the game structure, for example, by looking at permutations of players that induce the same payoff structure, al...
] did not fully utilize the existing theoretical results of Hilbert-type inequalities, resulting in a very complex proof process. In response to these shortcomings, this paper uses the construction theorem of homogeneous kernel Hilbert-type integral inequalities from ref. [...
Chinese Journal of Tissue Engineering Research|Vol 28|No.8|March 2024|1295 中国组织工程研究 www.CJTER.com Chinese Journal of Tissue Engineering Research 综述 and in basic studies, the mechanism of gout-causing bone destruction can be divided into the five aspects: (1) Sodium acid crystals have...