Cell and tissue interactions in the reproduction of cell type - HAUSCHKA - 1965Konigsberg, I. R., and Hauschka, S. D., 1965, Cell and tissue interactions in the reproduction of cell type, in: Reproduction: Molecular, Subcellular, and Cellular (M. Locke, ed.), pp. 243–290, Academic ...
Step-by-Step Solution:1. Understanding Unicellular Organisms: Unicellular organisms are made up of a single cell that performs all necessary functions for survival. Examples include bacteria, amoeba, and parame
Deer antlers are extraordinary mammalian organs that can fully regenerate annually. Antler renewal is a stem cell-based epimorphic process and antler stem (AS) cells can initiate de novo generation of antlers in postnatal mammals. However, although being
Although enormous insights on cell type proportion changes have been drawn from the applications of these deconvolution methods, most of these downstream analyses were performed under the scheme of single signature matrix, i.e., the same signature matrix was used for different groups of bulk data. ...
The rapid development of single-cell transcriptomic technologies has helped uncover the cellular heterogeneity within cell populations. However, bulk RNA-seq continues to be the main workhorse for quantifying gene expression levels due to technical simpl
The importance of cell type-specific epigenetic variation of non-coding regions in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are conspicuously lacking. We generate cell type-specific whole-genome methylomes (N = 95) and transcriptomes (N = 89) from...
Systematic characterization of how genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and chromatin accessibility in cells
In the analysis of high-throughput data from complex samples, cell composition is an important factor that needs to be accounted for. Except for a limited number of tissues with known pure cell type profiles, a majority of genomics and epigenetics data r
promoters. Replicate biological samples of each cell-type cluster together (Fig.1f), demonstrating that any differences in the measured ChIP-MNase profiles arise primarily from biological differences between cell-types, and not from inadvertent differences in sample preparation or treatment. We next ...
Elucidating brain cell type specific gene expression patterns is critical towards a better understanding of how cell-cell communications may influence brain functions and dysfunctions. We set out to compare and contrast five human and murine cell type-specific transcriptome-wide RNA expression data sets...