Eksp. Biol. Med. 143: pp. 128-131Balezina O.P., Bogacheva P.O., Orlova T.Y. Effect of L-type calcium channel blockers on activity of newly formed synapses in mice // Bull. Exp. Biol. Med. - 2007. - Vol. 143, №2 - P.171-4....
Effect of L-type calcium channel blockers on activity of newly formed synapses in mice 来自 国家科技图书文献中心 喜欢 0 阅读量: 21 作者:OP Balezina,PO Bogacheva,TY Orlova 摘要: Verapamil (5 M), nifedipine (10 M), and ryanodine (10 M) potentiated rhythmic activity of newly formed ...
Protective effect of L-type calcium channel blockers against haloperidol-induced orofacial dyskinesia: a behavioural, biochemical and neurochemical study. Neurochem Res. 2008c;33:1869–80.Bishnoi M, Chopra K, Kulkarni SK. Protective effect of L-type calcium channel blockers against haloperidol- ...
Background Low-voltage-activated (T-type) calcium channels play a crucial role in a number of physiological processes, including neuronal and cardiac pacemaker activity and nociception. Therefore, finding specific modulators and/or blockers of T-type channels has become an important field of drug di...
Calcium channel blocker Drug design T-type HipHop Introduction The voltage gated calcium (Ca2+) channels (VGCCs), in response to membrane depolarization, mediate the rapid influx of extracellular Ca2+ ions into the cytosol of electrically excitable cells [1], [2]. The increase in the cytosolic...
Effects of L-type calcium channel blockers on tramadol-induced analgesia in mice; L-型钙通道阻断剂对曲马多镇痛作用的影响补充资料:钙通道阻滞剂 钙通道阻滞剂 calcium channel blockers 又称“钙拮抗剂”、“慢通道阻滞剂”。指能选择性的阻滞细胞膜上的钙通道,减少Ca2+经钙通道内流的一类药物。主要有二...
Over the past three decades, L-type Ca2+ channel (LTCC) blockers have been considered a potential therapeutic drug to alleviate the symptoms of drug addiction. This idea has been supported, in part, by 1) expression of LTCCs in the brain dopaminergic circuits that are thought to play critic...
Takuya Seko,et al.L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models.Bioorganic and Medicinal Chemistry Letters. 2002Takuya Seko,et al.L-Cysteine based N-type calcium channel blocker...
Earlier, we had reported that co-administration of opioids and L-type calcium channel blockers (L-CCBs) like diltiazem could prove useful in the treatment of cancer pain. Much of this report was based upon earlier published work involving animal models of pain exposed to brief periods of noxio...
Several agents that are preferential T-type calcium (T-channel) blockers have shown promise as being effective in alleviating acute and chronic pain, suggesting an urgent need to identify even more selective and potent T-channel antagonists. We used small, acutely dissociated dorsal root ganglion ...