Documented high expression of RBPs in the human brain led us to explore therapeutically targetable RNA–RBP complexes that may drive IDH-wild-type gliomas28,29. To discover RNA–RBP complexes that could potentially regulate recruitment of GAMs, we set out to first identify candidate RNAs that ...
of swollen web site detection by means of scintigraphic images. However, since the radiotracer is adsorbed onto the liposome area by electrostatic causes, it is strongly recommended that a neutral radiopharmaceutical be used to verify the potential of this formulation as a scintigraphic probe for ...
For example, rapalog inhibitors of mTOR have been shown to mitigate seizures in certain contexts [36]. We sought to determine whether mTOR controls the same set of target genes in brain. We treated mice for 1 h with AZD-8055, an ATP-competitive inhibitor of mTOR that has been shown to ...
Patients often suffer from reduced visual acuity of various causes. Between 60–80% of patients have cataracts [1, 10, 11], which are usually presenile posterior subcapsular lenticular opacities that rarely require removal. However, cortical wedge opacities may be present from near birth. Optic ...
and κ-carrageenan coating decreased large-scale shrinking of this fresh cut apples. L. plantarum TPB21.12 stayed viable in the delicious coating suspensions during storage space and ended up being energetic against Escherichia coli TPB21.8, a model bacterium for biotic component that causes food spoi...
Autosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disease with severe microcephaly at birth due to a pronounced reduction in brain volume and intellectual disability. Biallelic mutations in the WD repeat-containing protein 62 gene WDR62 are the genetic cause of MCPH2. Howev...
Nevertheless, the load that this condition can exert on the β-cell function at the pubertal transition is such as to determine its rapid and irreversible deterioration leading to plain diabetes. The aim of this review is to highlight, in the context of metabolic syndrome, age-specific risk ...
Febrile seizures are often triggered by a fever from a common childhood illness such as roseola, a viral infection that causes a high fever, swollen glands and a rash. 大约4%的小于5岁的小孩会发生因发烧导致的痉挛(发烧痉挛)。在小孩的温度迅速地升高或者降低的时候,痉挛的症状就发生了,包括暂时失去...
The mouse mutation opisthotonus, which causes seizures and ataxia without obvious neuronal loss, results from a defect in the calcium release channel, type 1 inositol 1,4,5-triphosphate receptor, leading to a disruption in the control of intracellular Ca2+ stores Matsumoto et al. 1996, Street ...
Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct modulation effects in different neuron populations, then the mechanism can be unde