四型分泌系统 (type IV secretion system, T4SS) 是一种在革兰氏阴性菌 、革兰氏阳性菌和古细菌中均广泛存在的多功能、多组分的跨膜通道结构,将DNA,蛋白质或其他大分子递送至靶细菌或真核细胞。与细菌中已发现的其它分泌系统不同,T4SS形成的管道既能通过蛋白质又能通过DNA,因此T4SS能够介导细菌接合转移、DNA释...
Anconstituent that augments cancer risk is the strain-specificpathogenicity island, which encodes a type IV secretion system (T4SS) that translocates a pro-inflammatory and oncogenic protein, CagA, into epithelial cells. However, the majority of persons colonized with CagAstrains do not develop ...
首先，我们将探讨根癌土壤杆菌（Agrobacterium tumefaciens）VirB/VirD4 T4SS的“最小化”系统，然后介绍由幽门螺杆菌（Helicobacter pylori）Cag、嗜肺军团菌（Legionella pneumophila）Dot/Icm以及F质粒编码的Tra系统代表的“扩展”系统。根癌土壤杆菌VirB/D系统是T4SS的基本模型，它由约12个保守亚基组成。...
et al. TraG-like proteins of DNA transfer systems and of the Helicobacter pylori type IV secretion system: inner membrane gate for exported substrates? J. Bacteriol. 184, 2767–2779 (2002). Article CAS PubMed PubMed Central Google Scholar Tato, I., Zunzunegui, S., de la Cruz, F. & ...
(1.2.5) 第四型分泌系统(Type IV secretion system)……… 6 (1.3) 幽门螺旋杆菌CagA蛋白及第四型分 …www.alllw.com|基于5个网页 2. 第四分泌系统 ...体(Bartonella henselae)能通过第四分泌系统( type IV secretion system )将DNA转移到人的细胞中去,此项研究发表在PNA…blog.sciencenet.cn|基于1 ...
Schulein, R. & Dehio, C. The VirB/VirD4 type IV secretion system ofBartonellais essential for establishing intraerythrocytic infection.Mol. Microbiol.46, 1053–1067 (2002). ArticleCASPubMedGoogle Scholar Watarai, M., Andrews, H. L. & Isberg, R. Formation of a fibrous structure on the su...
Several appendages are assembled at thebacterial cellsurfaceby machinery resembling previously described secretion systems. That is the case for flagella andT3SS, type IV pili,T2SSor conjugative pili, andT4SS[244]. Whether these machines are named for the secretion system they are similar to var...
Other characterized T6SS components are: a ClpVATPasebelonging to the AAA+family, a regulatory FHA (forkhead-associated) domain protein that is the target of a couple of Ser/Thr kinase and phosphatase, DotU- and IcmF-like proteins homologous totype IV secretion system(T4SS) components, and ...
Cui LL, Shao SH (2007) The type IV secretion system encoded by the cag PAI of Helicobacter pylori. Wei Sheng Wu Xue Bao = Acta Microbiologica Sinica 47(4):743-745Cui LL,Shao SH.The type IV secretion system encoded by the cag PAI of Helicobact- er pylori. Wei Sheng Wu Xue Tong ...
The type IV secretion system (T4SS) encoded by the virB operon is essential for establishing persistent infection by Bru- cella spp. in mice (10, 17, 35, 38). In addition, it has been shown to contribute to intracellular survival in in vitro models of infection by allowing the vacuole ...