Florova et al., " Cloning, Expression and Characterization of a Type II 3-Dehydroquinate Dehydratase Gene from Streptomyces Hygroscopicus, " Archives of Biochemistry and Biophysics, 350(2):298-306 (1998).Florova G, CD Denoya, MR Morgenstern, DD Skinner and KA Reyn- olds. 1998. Cloning, ...
The reaction pathway of Schiff base hydrolysis catalyzed by type I dehydroquinate dehydratase (DHQD) fromS. entericahas been studied by performing molecular dynamics (MD) simulations and density functional theory (DFT) calculations and the corresponding potential energy profile has also been identified. ...
Q. Pan, Y. Yao, Z.S. Li, New insights into the mechanism of the Schiff base formation catalyzed by type I dehydroquinate dehydratase from S. enterica, Theory Chem. Acc. 131 (2012) 1-11.Pan Q, Yao Y, Li ZS (2012) New insights into the mech- anism of the Schiff base formation ...
Dehydroquinase (3-dehydroquinate dehydratase, DHQD, EC 4.2.1.10) catalyzes the conversion of dehydroquinate to dehydroshikimate. DHQD fromAcinetobacter baumannii(AbDHQD) was cloned, expressed and purified to homogeneity. The binding studies showed that two compounds quinic acid and citrazinic acid bound ...
Dehydroquinase (3-dehydroquinate dehydratase, DHQ, EC 4.2.1.10) is the third enzyme in the shikimic acid pathway, and catalyses the reversible dehydration of 3-dehydroquinic acid (1) to 3-dehydroshikimic acid (2) (Scheme 1). Biochemical...
The dehydroquinate dehydratase II (DHQase II) is considered a key enzyme of shikimate pathway, and it can be used as a promising target for the design of new bioactive compounds with antibacterial action. The aim of this work was the construction of QSAR models to aid the design of new ...
The biosynthetic shikimate pathway consists of seven enzymes that catalyze sequential reactions to generate chorismate, a critical branch point in the synthesis of the aromatic amino acids. The third enzyme in the pathway, dehydroquinate dehydratase (DHQD), catalyzes the dehydration of 3-dehydroquinate ...
The key factors on the structure, binding, and affinity of the inhibitors have been also highlighted. This may direct the further development of type II Mycobacterium tuberculosis dehydroquinate dehydratase inhibitors as potent tuberculosis drugs.YaoYuanZe-ShengLiCurrent Topics in Medicinal Chemistry...
Dehydroquinate dehydratase (DHQD) catalyzes the third reaction in the biosynthetic shikimate pathway. Type I DHQDs are members of the greater aldolase superfamily, a group of enzymes that contain an active site lysine that forms a Schiff base intermediate. Three residues (Glu86, His143, and Lys...
A gene encoding dehydroquinate dehydratase (DHQase) was cloned fromStreptomyces hygroscopicusvar.ascomyceticus.The 528-bp open reading frame specified a primary translation product of 175 amino acids with a calculatedMrof 18,789. The predicted amino acid sequence of the DHQase showed similarities to...