I型干扰素(Type I Interferons, IFN-I)是一种具有强效抗病毒活性的细胞因子,同时也是免疫系统的重要调节分子,主要包括IFNα和IFNβ。I型干扰素相关疾病是近10年来提出的一组比较新的疾病,『Ⅰ型干扰素病的免疫学基础』https://mp.weixin.qq.com/s?__biz=MzkzNzIyNjUxOQ==&mid=2247490716&idx=1&sn=2bf790...
Hepatitis B virus (HBV) can cause chronic hepatitis B, which may lead to cirrhosis and liver cancer. Type I interferon (IFN) is an approved drug for the treatment of chronic hepatitis B. However, the fundamental mechanisms of antiviral action by type I I
Human IFN Alpha Hybrid Protein (Universal Type I IFN) 11200-1由上海拜力生物科技有限公司供应,该产品简介:重组蛋白杂合通用 I 型干扰素由 PBL Assay Science(目录号 #11200-1)生产,仅供研究使用 (RUO),包装为 1...
上海玉博生物科技有限公司 主要致力于“Universal Type I IFN R&D-11200-2”的生产销售。多年的“Universal Type I IFN R&D-11200-2”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前来选购
iLite® Type I IFN Assay Ready Cells (BM3049) 由上海拜力生物科技有限公司供应,该产品简介:iLite® Type I IFN Assay Ready Cells (BM3049)
Type I interferons (IFNs) are potent mediators of the innate immune response against viruses and cancer. There are 16 members of the type I IFN family (IFNβ, IFNɛ, IFNκ, IFNω and 12 IFNα subtypes), which signal through the same receptor — composed of the subunits IFNAR1 and ...
The Type I IFN-Induced miRNA, miR-21 The interferon (IFN) family of cytokines not only has antiviral properties at various steps in the viral replication cycle, but also anticancer activity th... C Yang,K Li,S Pfeffer,... - 《Pharmaceuticals》 被引量: 28发表: 2015年 The Type I IFN-...
Furthermore, type I IFN activates the downstream IFN/JAK/STAT pathway to modulate expression of a set of genes against viral infection, but whether these genes can feedback regulate type I IFN production is poorly understood. In this study, by screening the microRNAs modulated by viral infection...
Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment and the activation of type I interferon (IFN)...
结果显示B18R下调了MitoStress诱导的内皮细胞IFN基因的表达。而Infliximab降低了MitoStress诱导的内皮细胞TNF基因的表达。CXCL10和CXCL11的表达只在阻断TNFa后下调。 Fig 4d:随后作者探究了是否mitochondrial activity可以影响MitoStress诱导type I IFN 和 TNF 信号通路的。分离自ρ0 THP-1 monocytic 或 THP-1 的Mito...