TwoSampleMR包出现报错:Error in format_data(as.data.frame(exposure_dat), type = "exposure", snps = NULL, : None of the specified columns present 解决方案:统一列之间的分隔符,比如都统一为空格或者逗号等
42]. Moreover, the SLE GWAS SNPs were enriched in SPI1 ChIP-seq (Fig. S11) and the top GWAS SNPs for SLE corresponded to a known SPI1 motif. These results suggest that the ΔMOCCS2score can be used to predict the cell types in which GWAS-SNPs potentially influence TF-binding specific...
Exposure or OutcomeUnitParticipants Included in AnalysisAdjustmentsIdentified SNPsPubMed ID or URL BMI SD 339,224 individuals of multiancestries Age and any necessary study-specific covariates 97 25673413 Waist circumference SD 224,459 individuals of European ancestry Age and study-specific covariates 47...
Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters or super-enhancers. So far, such domains have been defined thro
The membrane was visualized by autoradiography after an overnight exposure. End sequences from positive clones were obtained from the TIGR database (http://www.tigr.org/tdb/bac_ends/mouse/bac_end_intro.html). Markers were designed from these sequences and tested for amplification from YAC 43...
The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the β-cell regulatory landscape. We expand the repertoire...
Steiger filtering was further applied to exclude single-nucleotide polymorphisms (SNPs) that were correlated with an outcome (T2DM) stronger than exposure (education attainment).#We observed 598 new diabetes cases after 10.4years of follow-up. The adjusted hazard ratios (95% CI) of T2DM were ...
Relative grip strength (RGS) and timed up and go (TUG) test were examined at baseline and results of those were combined to create a composite exposure RGS-TUG score. Grip strength was assessed using a Jamar Hydraulic Hand Dynamometer two times for each hand, and the maximal value of the ...
Complex multifactorial diseases of this kind are associated with the effects of multiple genetic loci combined with a variety of environmental factors, such as diet, lifestyle and exposure to toxins. The burden of complex disease is not evenly distributed within or between countries in Latin America...
(GO:0009055) are also highly enriched. Given the fact that many Ranunculales taxa are undergrowth plants in relatively high altitudes, the enrichment of genes in these two GO categories may improve their adaptability under stress exposure (e.g., absence of light, low temperature, or high ...