Type B insulin resistance syndrome (IRS) is characterised by production of autoantibodies against the insulin receptor (IR). These autoantibodies block insulin binding to the IR, resulting in severe insulin resistance. Some patients with this syndrome paradoxically exhibit episodic hypoglycaemia. Relatively...
Review BB Kahn - 《Cell》 被引量: 845发表: 1998年 Role of Lipid Oxidation in Pathogenesis of Insulin Resistance of Obesity and Type II Diabetes Increased lipid oxidation is generally observed in subjects with obesity and diabetes and has been suggested to be responsible for the insulin ...
Insulin resistance is a core feature of T2DM and is emerging as a potentially important feature of ADRDs. Here, we review key observations and experimental data on insulin signalling in the brain, highlighting its actions in neurons and glia. In addition, we define the concept of 'brain ...
Insulin resistance is a core feature of T2DM and is emerging as a potentially important feature of ADRDs. Here, we review key observations and experimental data on insulin signalling in the brain, highlighting its actions in neurons and glia. In addition, we define the concept of 'brain ...
Free iron status & insulin resistance in type 2 diabetes mellitus: Analyzing the probable role of a peanut protein 来自 Semantic Scholar 喜欢 0 阅读量: 21 作者:S Sen,SK Ghatak,D Majumdar,K Sen,B Bhattacharya 摘要: Peanut proteins conarachin II, conarachin I and arachin were found to ...
This review will focus on the importance of insulin resistance and beta-cell dysfunction in the pathogenesis of Type 2 diabetes. In the course of the discussion, it will be apparent that changes in beta-cell function are both an early and critical component in the pathogenesis of the hyperglyca...
A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR). Hypogonadal men are at higher risk for T2D. Here we evaluate the relationships between testosterone, metabolic syndrome (MetS), T2D, and IR and...
The long-term inflammatory condition cause of insulin resistance and the development of T2D115. Figure 6 Verification of the proposed drug-targets (shared KGs) and drug-agents for T2D and CRC by the literature review. (A) Verification of the proposed drug-targets, (B) Verification of the ...
HOMA-B: Homeostasis model assessment of pancreatic islet β-cell function HOMA-IR: Homeostasis model assessment of insulin resistance IL-1: Interleukin-1 IL-10: Interleukin-10 IL-17: Interleukin-17 IL-4: Interleukin-4 IL-5: Interleukin-5 IL-6: Interleukin-6 iNOS: Inducible nitric...
Critical review: assessment of interferon-β immunogenicity in multiple sclerosis. J. Interferon Cytokine Res. 30, 759–766 (2010). Article CAS PubMed Google Scholar The IFNB Multiple Sclerosis Study Group. Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical ...