Other causes of hyperkalemia were excluded in the present case. Serum levels of potassium returned to normal when fludrocortisone was added to the bicarbonate supplementation. This case of severe hyperkalemic secondary to type 4 RTA after kidney transplantation only responded to the combination of ...
The two main genetic causes of senescence, antagonistic pleiotropy and mutation accumulation, have different expectations with regard to the frequency distribution of mutations that are deleterious to the older age classes of a species (Rodrguez et al.2016). Here we considered the consequence of popu...
In parallel to genome sequencing, RNA-seq and small RNA-seq was performed for 10 individuals: three affected individuals (1-III-16, 1-IV-9, and 1-IV-11) and one healthy spouse (1-III-24) from Family 1, three affected individuals (5-III-2, 5-III-3, and 5-IV-4) from Family 5...
a有太多的私家车会导致废气污染严重,过多则影响交通问题,导致更多交通事故 Has the too many private vehicle to be able to cause the waste gas pollution to be serious, excessively many affects the transportation question, causes the more traffic accident[translate] ...
ZBP1 causes pathology inAdar1mZα/–mice The finding that hemizygous expression of ADAR1 with a mutated Zα domain causes severe pathology in both humans and mice indicates that the capacity of ADAR1 to bind Z-RNA is critical to prevent pathogenic IFN responses, but the underlying mechanisms ...
Editor's summary: Schistosomiasis infection causes more than 230 million infections worldwide, but immune responses during acute infection are not well understood. To better observe these responses, Houlder et al. used controlled human Schistosoma mansoni infections with either m...
In this report we describe a new case of ALPS Type Ib due to a gene mutation that causes a functional alteration of the FasL protein. We found that the mutant protein associates with wild-type FasL and by so doing, dominantly interferes with apoptosis induction. These data strengthen the dom...
RNA interference–based knock-down and rescue experiments demonstrated that the p.P916R mutation causes cytokinesis failure in HeLa cells, consistent with appearance of large multinucleated erythroblasts in CDA III patients. We conclude that CDA III is caused by a mutation in KIF23/MKLP1, a ...
lwJret2r.h2ti–Tehe2dh0es6etso(rstTuaeraaitrnibtenolsheuh afSulart1rbrs)bto.ihonrTeridhnriniegvcgaeptttrhlehaiefsetymphptlailhaadtsesstmmhbweiaidedcirntpepetaraieniiirarrtalrppcottBBwdioThuonrhc-chpebCdaye3Sbt4iLwn–rN3it7ed5o04e//antpphsTTsHeahhrryrrecccprCJJeo22s22aru––tn22el00...
In most cases, infection causes chronic active gastritis but remains largely asymptomatic1. However, the course of the disease can also be associated with symptomatic gastritis and the development of gastric and duodenal ulcers2 and even more severe alterations of the gastric mucosa including malignant...