ILC2eosinophilsmelanomaimmunotherapyanti-PD-1Immunity to melanoma is thought to be mainly mediated by adaptive immune cells. To what extent innate immunity, particularly innate lymphoid cells, drive the immune response and impact melanoma prognosis and therapeutic responsiveness is not well understood. In...
innate lymphoid cellsmucosal immunologyneuroimmunologytype 2 inflammationSummary Type 2 immunity against pathogens is tightly regulated to ensure appropriate inflammatory responses that clear infection and prevent excessive tissue damage. Recent researc... 查看全部>>doi:10.1111/imr.12702...
Innate lymphoid cells (ILCs) are a class of lymphocytes that do not express specific antigen recognition receptors, which play a significant role in variou
Group 2 innate lymphoid cells (ILC2s) are highly heterogeneous tissue-resident lymphocytes that regulate inflammation and tissue homeostasis in health and disease. However, how these cells integrate into the tissue microenvironment to perform tissue-specific functions is unclear. Here, we show neuropilin...
Type II innate lymphoid cells (ILC2s) maintain homeostasis and barrier integrity in mucosal tissues. In both mice and humans, ILC2s poorly reconstitute after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Determining the mechanisms invol
II型固有淋巴细胞白色脂肪组织棕色脂肪组织米色脂肪组织白色脂肪组织棕色化白细胞介素33Type II innate lymphoid cells ( ILC2s) are widely distributed in the blood , intestines, trachea, lung, spleen, liver, animal fat and skin, and involved in the innate immune responses .ILC2s have attracted ...
In addition, type 2 innate lymphoid cells were found to respond to anti-PD-1 antibody therapy26 and to release granzyme B for direct lysis of tumour cells27, thereby contributing positively to the antitumour efficacy. Depending on the source, local concentration and responding cells, type 2 ...
I-L-C-2 it type 2 immunity and group 2 innate lymphoid cells in homeostasis 热度: IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4 Th17 cells 热度: RESEARCHHlGHLlGHT ...
Burton OT, J Medina Tamayo, AJ Stranks, S Miller, KJ Koleoglou, EO Weinberg, et al. IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy. 2018; 48(3):288-96.Burton OT, Medina Tamayo J, Stranks AJ, Miller S, Koleoglou KJ, Weinberg EO, et al. IgE...
Type 2 innate lymphoid cells (ILC2s) were discovered approximately ten years ago and their clinical relevance is gaining greater importance. However, their successful isolation from mammalian tissues and in vitro culture and expansion continues to pose challenges. This is partly due to their scarcity...