The type 2 diabetes knowledge portal: accelerating type 2 diabetes research through community access to human genetic information and toolsdoi:10.7490/F1000RESEARCH.1111705.1M. CostanzoF1000Research
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol spec
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic assoc
Type 2 Diabetes Knowledge Portal. https://t2d.hugeamp.org/region.html?chr=6&end=118081803&phenotype=HEIGHT&start=117946665 (2021). Wu, C., Jin, X., Tsueng, G., Afrasiabi, C. & Su, A. I. BioGPS: building your own mash-up of gene annotations and expression profiles. Nucleic Acids...
The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. Methods Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from...
ARTICLE doi:10.1038/nature18642 The genetic architecture of type 2 diabetes A list of authors and affiliations appears in the online version of the paper The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual ...
Digital technology and its effects on knowledge improvement for diabetes management: An integrative review. Int J Nurs Pract. 2021. https://doi.org/10.1111/ijn.13029. Digital technologies are advantageous and impactful for patients with diabetes, although careful consideration of elements such as ...
Nutrition Á Diet Á Systems biology Á Type 2 diabetes Á Omics Introduction Type 2 diabetes (T2D), defined as hyperglycemia resulting from compromised insulin utilization (insulin resistance, IR) coupled with insufficient compensatory insulin pro- duction, is the common form of diabetes ...
Type 2 Diabetes Knowledge Portal http://www.type2diabetesgenetics.org/home/portalHome (2019). Kanai, M. et al. Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Nat. Genet. 50, 390–400 (2018). Article CAS PubMed Google Scholar ...
Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms that underlie it are unclear. Here, we examine genetic determinants of cardiorespiratory fitness