The Type 2 Diabetes Knowledge Portal (T2DKP) is a public resource of genetic datasets and genomic annotations dedicated to type 2 diabetes (T2D) and related traits. Here, we seek to make the T2DKP more accessible to prospective users and more useful to existing users. First, we evaluate ...
Type 2 diabetes mellitus, the most frequent subtype of diabetes, is a disease characterized by high levels of blood glucose (hyperglycaemia). It arises from a resistance to and relative deficiency of the pancreatic β-cell hormone insulin. ...
The type 2 diabetes knowledge portal: accelerating type 2 diabetes research through community access to human genetic information and toolsdoi:10.7490/F1000RESEARCH.1111705.1M. CostanzoF1000Research
Type 2 Diabetes Knowledge Portal. https://t2d.hugeamp.org/region.html?chr=6&end=118081803&phenotype=HEIGHT&start=117946665 (2021). Wu, C., Jin, X., Tsueng, G., Afrasiabi, C. & Su, A. I. BioGPS: building your own mash-up of gene annotations and expression profiles. Nucleic Acids...
SIGMA Genetic Data Type 2 Diabetes Knowledge Portal http://www.type2diabetesgenetics.org Experimental Models: Cell Lines HEK293T Broad Genetic Perturbation Platform N/A BSG-knockout HEK293T #1 This paper N/A BSG-knockout HEK293T #2 This paper N/A HuH7 Cancer Cell Line Encyclopedia (CCLE)...
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol spec
ARTICLE doi:10.1038/nature18642 The genetic architecture of type 2 diabetes A list of authors and affiliations appears in the online version of the paper The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual ...
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestr
Nutrition Á Diet Á Systems biology Á Type 2 diabetes Á Omics Introduction Type 2 diabetes (T2D), defined as hyperglycemia resulting from compromised insulin utilization (insulin resistance, IR) coupled with insufficient compensatory insulin pro- duction, is the common form of diabetes ...
We further explored Type 2 Diabetes knowledge portal (https://t2d.h ugeam p.o rg/) for these genes and found the association of FOXA2, HNF4A, NR0L2, SUMO1, CDK2, MAPK3, HDAC3, and MYOD1 with glycemic, lipid, and anthropometric traits based on meta-analysis of ...