Corona virus spread in humans in December 2019 in Wuhan, China. The purpose of this study was to investigate the relationship between type 2 diabetes mellitus (T2DM), and their biochemical and hematological factors with the level of infection...
Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms that underlie it are unclear. Here, we examine genetic determinants of cardiorespiratory fitness in 450k European-ancestry individuals in UK Biobank...
Although it can occur at any age, the peak age for diagnosis of type 1 diabetes is in the mid-teens. The peak age of onset of type 2 diabetes mellitus (T2DM), which was previously known as non–insulin-dependent diabetes mellitus or adult-onset diabetes, is typically later than that of...
Comprehensive screening for non-alcoholic fatty liver disease (NAFLD) may help prompt clinical management of fatty liver disease. A family history, especially of diabetes, has been little studied as a predictor for NAFLD. We characterized the cross-secti
The dose-response analysis revealed a linear increase in risk with the number of hours per day of TV viewing for both type 2 diabetes and cardiovascular disease; the association with all-cause mortality appeared stronger with TV viewing time of greater than 3 hours per day. However, more studi...
Exergaming is a novel approach to increase motivation for regular physical activity (PA) among sedentary individuals such as patients with type 2 diabetes mellitus (T2DM). Because existing exergames do not offer fitness-level adjusted, individualized workouts and are normally stationary (TV bound), th...
Cardiovascular disease is a common comorbidity of type 2 diabetes (T2D), affecting approximately one-third of patients with T2D worldwide [1]. In addition to being a risk factor for the development of coronary heart disease, diabetes also affects the prognosis of acute coronary syndrome (ACS) ...
We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate such data and applied it to a cohort of 789 people with newly diagnosed type 2 diabetes with deep multi-omics phenotyping from the DIRECT consortium. Using in silico perturbations, we ...
Type-2 diabetes mellitus (T2DM) therapy requires early diagnosis and complication avoidance. Unfortunately, current diagnostic markers do not meet these needs. Data-independent acquisition mass spectrometry (DIA-MS) offers a solution for clinical diagnosis, providing reliable and precise sample quantificatio...
Living in a northern climate is a risk factor that has not been fully explained. What is the difference between type 1 and type 2 diabetes? The major process that happens in type 1 diabetes is that the pancreas can no longer produce insulin. Type 2 diabetes is more a result of insulin ...