B cellsT-betCXCL9CXCL10Rheumatoid arthritisEfficacy of B-cell depletion therapy highlights the antibody-independent effector functions of B cells in rheumatoid arthritis (RA). Given type 1 helper T (Th1) cells abundant in synovial fluid (SF) of RA, we have determined whether Th1 cells could ...
endothelial cellshyperglycemiaT helper cellTo observe the changes of type 1 T helper cells (Th1)/type 2 T helper cells (Th2) in peripheral blood of the patients with coronary heart disease (CHD) under different blood glucose conditions, and to investigate the involvement of the changes of Th1...
Correlations of T helper type 1 cells (Th 1) and serum adiponectin with blood pressure in mice fed NCD, HFD or bilberries in HFD.Otto T. MykkänenAnne HuotariKarlHeinz HerzigThomas W. DunlopHannu MykkänenPirkka V. Kirjavainen
IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, ...
The existence of two functionally distinguished populations among T cells has been established in both mice and humans. Type 1 T helper (Th1) cells are involved in the defense against intracellular bacteria and many viruses, while type 2 Th cells (Th2) are the major actors in the response ag...
the magnitude of antitumor immune responses are critically affected by DC functions, including production of T helper type 1 (Th1)-inducing cytokines, activation of T cell subsets and natural killer (NK) cells, and migration from peripheral tissues to the T cell area of the draining lymph nodes...
T regulatory type 1 cells (TR1 cells). A subset of immunosuppressive CD4+T cells that downregulate T helper 1 (TH1) and TH2 cell responsesin vitroandin vivoby a contact-independent mechanism that is mediated by the secretion of soluble interleukin-10 and transforming growth factor-β1. ...
Tissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar ...
We have generated mice with a deficiency in T1/ST2 expression to clarify the roles of T1/ST2 in T helper cell type 2 (Th2) responses. Using immunological challenges normally characterized by a Th2-like response, we have compared the responses of T1/ST2-deficient mice with those generated by...