Initiation of two trials; Focus on helping to prevent the disease or stop it from progressing after diagnosis; Details of the two trials; Background on the network, Type I Diabetes TrialNet.doi:10.1001/jama.292.4.426-dTracy HamptonJama Journal of the American Medical Association...
Type 1 diabetes (T1D) is often first recognized when signs and symptoms occur, yet the patho-genetic development of T1D usually begins years before that. Pancreatic autoantibodies commonly become elevated long before diagnosis (1). Although data indicate that the first-phase insulin response (FPIR...
Type 1 Diabetes Vaccine Shows Promise In Small TrialmntScience Translational Medicine
The AJMC® Type 1 Diabetes compendium is a comprehensive resource for news and interviews about this chronic autoimmune condition.
Controlled Clinical TrialsOrban T, Sosenko JM, Cuthbertson D, et al.; Diabetes Prevention Trial-Type 1 Study Group. Pancreatic islet autoanti- bodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Di- abetes Care 2009;32:2269-2274...
The U.S. Food & Drug Administration (FDA) has granted Investigational New Drug (IND) regulatory clearance to initiate a Phase I/II clinical trial evaluating Alpha-1 Antitrypsin (AAT) in type 1 diabetics, based on research by Dr. Eli Lewis of Israel's Ben
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1 diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose dysregulation. The recent regulatory approval of the first immunotherapy that targets T cells as a means to de...
Participant Flow Through Type 1 Diabetes TrialNet Study View LargeDownload Figure 2. The Proportion of Study Individuals Who Had Not Developed Type 1 Diabetes as a Function of Follow-up View LargeDownload The plus marks indicate that the participants were censored. A, The quartiles of time ...
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The use of a standardized outcome metric enhances clinical trial interpretation and cross-trial comparison. Here, the authors show the implementation of such a metric using type 1 diabetes trial data, reassess and compare results from these trials, and extend its use to define response to therapy...