In T1DM, the rate of 尾-cell destruction varies. Whereas infants and children tend to demonstrate rapid 尾-cell death, adults typically present with a lengthy prodromal phase leading to latent autoim- mune diabetes of adulthood (LADA).8 Some patients, particularly children and adolescents, may ...
Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated inflammation and hyperglycemia in T1DM mouse...
Type 1 diabetes mellitus (T1DM) is caused by autoimmune destruction of the insulin-secreting cells within the islets of Langerhans and Type 1 diabetic patients generally require exogenous insulin to survive. The autoimmune nature of this disease was elegantly demonstrated when a recipient affected by ...
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell loss and leads to hyperglycaemia. Although the age of symptomatic onset is usually during childhood or adolescence, symptoms can sometimes develop muc...
Type-1 diabetes mellitusPancreasInsulinStem cell therapyEmbryonic stem cellsAdult stem cellsInsulin-secreting cellsRegenerative medicineType-1 diabetes mellitus (T1DM) is a chronic, multifactorial autoimmune disease involving progressive destruction of pancreatic β cells, ultimately resulting in loss of ...
MELANOMAAlthough there have been also known that a few cases may develop T1DM during adjuvant use of programmed deathinhibitors, its clinical course has not ever been described in detail. This report presents the case of type 1 diabetes mellitus related to adjuvant nivolumab therapy....
Type 1 diabetes mellitus (T1DM) is a complex disease requiring constant vigilance and special training to ensure healthy outcomes. A collaborative relationship between the child with T1DM and his or her parents is essential for proper monitoring and care. Adolescence rep...
PURPOSE: This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibodies] in Korean patients with type 1 diabetes (T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalenc...
Loss of functional β-cell mass is the key mechanism leading to the two main forms of diabetes mellitus — type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Understanding the mechanisms behind β-cell failure is critical to prevent or revert disease. Basic pathogenic differen...
Type 1 diabetes (T1DM) is a disorder of insulin deficiency that results from cell-mediated autoimmune pancreatic beta cell destruction. Previously known as juvenile diabetes or insulin-dependent diabetes, it accounts for 5–10 % of all cases of diabetes and >80 % of diabetes in young children ...