The development of the iHSMGC will facilitate further studies on the human skin microbiome. In the present study, it was used to further characterize the human skin resistome. It also allowed to discover the existence of two cutotypes on the human skin. The latter finding will contribute to ...
However, the molecular mechanisms underpinning the intergenerational effects remain unclear. Using a mouse model of diabetes during pregnancy, we found that intrauterine hyperglycemia exposure resulted in memory impairment in both the first filial (F1) males and the second filial (F2) males from the ...
and are actively expressed in some recipients Ting Sun1,2,3, Susanne S. Renner4,Yuxing Xu1,3,Yan Qin1,5, Jianqiang Wu1 & Guiling Sun1,2,5 A growing body of evidence is pointing to an important role of horizontal gene transfer (HGT) in the evolution of higher plants...
Here we report the derivation of two distinct stem cell types of the trophectoderm lineage from human pluripotent stem cells. Analogous to villous cytotrophoblasts in vivo, the first is a CDX2- stem cell comparable with placenta-derived TS cells—they both exhibit identical expression of key ...
Skeletal muscle, which makes up about 40% of human body mass8, undergoes extensive remodeling during spaceflight, leading to atrophy and loss of strength2,9,10. The decrease in leg muscle volume measured at landing after different missions is variable among crew members, approaching 40% in some...
Shared Gene Structures Reflect an Early Divergence of the Two Types of Maize SUN-domain Proteins The 2.3-Gb maize genome is partitioned among 10 structurally diverse chromosomes, which are predicted to encode over 32,000 genes [53]. The genetic map of maize is subdivided into approximately 100...
A significant proportion of the ESTs of each caste and life stages had no significant similarity to those in existing data bases. All cDNA libraries, including those of non-reproductive worker and soldier castes, contained sequences with putative reproductive functions. Genes that showed a potential...
The splicing of exon 4 into Rest is selective to a few cell types, including neurons, mechanosensory hair cells of the ear, and some cancer cells (Palm et al., 1999, Nakano et al., 2012). Exon 4 splicing into Rest requires the Ser-Arg-rich splicing factor SRRM4 in hair cells and ...
This communication is multifaceted, but one aspect is communication through compounds produced by the microbiota such as the short-chain fatty acids (SCFAs) butyrate, propionate and acetate. Studying the effects of SCFAs and especially butyrate in intestinal epithelial cell lines like Caco-2 cells ...
In this work, we comprehensively investigate pleiotropy across cancers by leveraging results from 257 published GWAS to systematically construct PRS specific to 16 cancer types. We then evaluate associations between each PRS and the risk of each cancer type in European ancestry individuals from two lar...