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Summary: We infer post-hybridization rearrangements in a hybrid genome, given the gene orders on its chromosomes and some knowledge of the two parent genomes. We study this in two biologically and computationally different contexts, geno... N Elmabrouk,D Sankoff - 《Lecture Notes in Computer Sc...
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In this study, we employed a two-sample MR framework to extensively investigate the causal effects of gut microbiota on infertility using summary data from genome-wide association study (GWAS). The primary objective of this research is to elucidate the underlying etiology of infertility related to ...
(N = 143,265) from the largest available genome-wide association studies. MR evidence suggested a causal relationship between higher relative carbohydrate intake and lower depression risk (odds ratio, 0.42 for depression per one-standard-deviation increment in relative carbohydrate intake; 95% ...
Here, we report the assembly and annotation of reference-grade genomes ofCn. tallandCn. dwarf, whose genome sizes are 2.40 Gb and 2.39 Gb, respectively. The comparative analysis reveals that the two coconut subspecies diverge about 2–8 Mya while the conserved Arecaceae-specific whole-genome dup...
Familial growth hormone deficiency provides an opportunity to identify new genetic causes of short stature. Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibro
IVs were chosen based on their significant genome-wide association with the exposure (P < 5e−8), a minor allele frequency above 0.01 in the outcome, and low linkage disequilibrium (LD) r2 within a 10,000 kb distance. SNPs associated with confounding factors or outcomes according to ...