Initiation of Protein Synthesis in E. Coli: The Two Crucial StepsOur lab has long studied the action of translational repressors (Miller et al., 1985; Andrake et al., 1988; Tuerk et al., 1990; McPheeters et al., 1988) and, more recently, a bacteriophage T4-encoded, Shine and ...
Microbial drug resistance motivates researchers to look for new materials to treat these harmful pathogenic microbes1. This search is particularly necessary in the light of the growing number of antibiotic-resistant strains and the greater challenges associated with infection treatment. Silver has been ut...
Such catalytic conformational promiscuity in glycosidases is related to the open architecture of the active site and thus might be extended to other exo-acting enzymes. These findings expand the current general model of catalytic mechanism of glycosidases, a main reaction in nature, and impact on ...
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The preparation procedure of LC-targeting immunoliposomes included two steps. Firstly, the immunoliposomes was prepared by thin-film dispersion method. EPC-3, cholesterol, mPEG2000-DSPE and Mal-PEG2000-DSPE (molar ratio = 2:1:0.008:0.002) were dissolved in anhydrous chloroform. Thereafter, the ...
Vascular Sources of Amino Acids for Milk Protein Synthesis in Goats at Two Stages of La... An arteriovenous kinetics technique was used to monitor mammary gland lysine and protein metabolism in goats (n=4) at two stages of lactation (80卤17 vs. 2... SJ Mabjeesh,CE Kyle,JC Macrae 被引...
The preprotein-conducting pore of TOC is a hybrid β-barrel co-assembled by Toc120 and Toc75, while the potential translocation path of TIC is formed by transmembrane helices from Tic20 and YlmG, rather than a classic model of Tic110. A rigid intermembrane space (IMS) scaffold bridges ...
Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionally, this has been done in two consecutive steps. The first step identifies important gen
As malignant cells harbor significantly more copy number variation (CNV) than normal cells, we estimated CNV from scRNA-seq following the steps described in the previous study56 and made some minor improvements. In brief, we first restricted our target cells to epithelial cells defined by both Si...
The dimeric hTop2β protein was shown as a surface representation and colored according to polypeptide chain. DNA was shown in yellow. Full size image In order to understand the mechanism of compound C-Bi, the structures of hTop2β-DNA binary complex and hTop2β-DNA-etoposide ternary complex...