3. Bostrom, Jenny et al. “Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.” Science (New York, N.Y.) vol. 323,5921 (2009): 1610-4. doi:10.1126/science.1165480 4. Schaefer, Gabriele et al. “A two-in-one antibody against HER3 and...
Two-in-one antibody: Herceptin variants that target HER2 and VEGFFuh, G
These variants with adaptive mutations have caused fresh outbreaks even amongst vaccinated populations.In the two new experimental medicines,the researchers fused an antibody called aRBD-2 with another two aRBD-5 and aRBD-7,respectively,according to the study published recently in the journal Cell R...
Secretory IgA is the major antibody class in the external body fluids of humans and is generated when secretory epithelial cells actively export locally pr... FE Johansen,P Brandtzaeg - 《Trends in Immunology》 被引量: 215发表: 2004年 Mucosal immunity of the gastrointestinal tract and oral tole...
Cells were permeabilised with 0.1% Triton X-100 for 15 min and then blocked with 2.5% (w/v) bovine serum albumin (BSA) in phosphate-buffered saline (PBS) for 1 h. MPO was probed for using mouse anti-myeloperoxidase antibody (ab25989, Abcam) at a 1:500 dilution. Cleaved-caspase...
This study investigated the usefulness of a two-serotype dengue mathematical model to gain insights into the effects of antibody-dependent enhancement and ... MZ Ndii,N Anggriani,BS Djahi,... - 《Journal of Biosafety & Biosecurity》 被引量: 0发表: 2024年 Models to assess the effects of no...
Guiding chemotherapy to a tumour by attaching it to the antibody-based target drug Herceptin (trastuzumab) is effective at treating women with breast cancer who have no other treatment options, a new clinical trial shows. The two-in-one treatment keptbreast cancerat bay in women with a type ...
The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the most abundant subclass, has a half-life as long as that of IgG2 and IgG4, binds the FcγR receptor, and ...
Xentuzumab, an insulin-like growth factor (IGF)-1/IGF-2-neutralising antibody, binds IGF-1 and IGF-2, inhibiting their growth-promoting signalling. Two first-in-human trials assessed the maximum-tolerated/relevant biological dose (MTD/RBD), safety, pharmacokinetics, pharmacodynamics, and activity...
Walker, T. L., et al.Prolactin stimulates precursor cells in the adult mouse hippocampus.PLoS One.7, (2012). Walker, T. L., et al.Latent stem and progenitor cells in the hippocampus are activated by neural excitation.J. Neurosci.28, 5240-5247 (2008). ...