The goal of this paper is to illustrate, by two unrelated actual examples of QSARs for mutagens and carcinogens, some fundamental problems relative to the application of general QSAR approaches to noncongeneric chemicals. Both examples consider data sets that are noncongeneric in a chemical ...
The involvement of BPV-1/2 in urinary bladder carcinogenesis is well recognized and the synergistic relationship between the virus and carcinogens from the fern has been experimentally reproduced [37]. The expression, localization and oncogenic activity of BPV E5 has been largely studied in BPV ...
An integrative exploratory analysis of –omics data from the ICGC cancer genomes lung adenocarcinoma study It is known that all agents that cause cancer (carcinogens) also cause a change in the DNA sequence. In order to identify such often subtle changes, we att... S Sikdar,HC Wosoba,Y Ab...
- 《Natural Antioxidants & Anticarcinogens in Nutrition Health & Disease》 被引量: 0发表: 1999年 2011Synthesis of Compliant Multistable Mechanisms Through Use of a Single Bistable Mechanism Although there are many examples of multistable compliant mechanisms in the literature, most of them are of ...
Peroxisome proliferator chemicals are classic non-genotoxic carcinogens. These agents cause liver cancers when chronically administered to rats and mice. P... FJ Gonzalez,YM Shah - 《Toxicology》 被引量: 371发表: 2008年 The Use of High-Efficiency Particulate Air-Filter Respirators to Protect Hospit...
Some of the toxic intermedi- ate metabolites include: teratogens (which cause malformations in the fetus), mutagens (which mutate cells) and carcinogens (which cause cancer). Vol. 21 No. 18 3 Thirdly, certain substances may Metabolic Byproducts also stimulate Phase 1 enzymes and cause an over...
depletes our soils and washes toxins into the ocean or into the air, produces endocrine disrupters to affect our hormonal systems, creates and distributes carcinogens, causes climate change, and dumps plastics in the oceans. if this was the design assignment, we’re doing great. if it’s not...
VIII. EXAMPLES I. Definitions Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described he...
An estimated 6,000 Americans died from the disease in 1988, and the number of cases is expected to rise. In some instances melanoma has been linked to blistering sunburns, but the disease is more likely related to genetic factors, viruses, and exposure to chemical carcinogens (cancer-causing...
The goal of this paper is to illustrate, by two unrelated actual examples of QSARs for mutagens and carcinogens, some fundamental problems relative to the application of general QSAR approaches to noncongeneric chemicals. Both examples consider data sets that are noncongeneric in a chemical ...