T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a...
Learn about xylem functions. Discover what xylem is and how it develops, examine images of what a xylem cell looks like, and study the cohesion tension hypothesis. Related to this Question Describe structural features of cell types in xylem, and how those features are critical for xylem...
Pluripotency and self-renewal, the defining properties of embryonic stem cells, are brought about by transcriptional programs involving an intricate network of transcription factors and chromatin remodeling complexes. The Nucleosome Remodeling and Deacetylase (NuRD) complex plays a crucial and dynamic role ...
Hematoxylin and eosin (H&E) stained sections were whole-slide imaged (WSI) at 20 × with a Nanozoomer S60 (Hamamatsu). Cancer regions of interest (ROI) and morphologic features in each block-face section WSI were annotated (Cytomine) (Additional file 1: Figs. S1 and S2). Cancer ...
Here we report the derivation of two distinct stem cell types of the trophectoderm lineage from human pluripotent stem cells. Analogous to villous cytotrophoblasts in vivo, the first is a CDX2- stem cell comparable with placenta-derived TS cells—they both exhibit identical expression of key ...
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes
Since the discovery of two-dimensional electron gas at the LaAlO3/SrTiO3 interface, its intriguing physical properties have garnered significant interests for device applications. Yet, understanding its response to electrical stimuli remains incomplete.
Research into the risk of anorexia nervosa (AN) has examined twin pairs to further the understanding of the contributions of genetics, trait inheritance, and environmental factors to eating disorder (ED) development. Investigations of twin experiences of
4. Specificity of RBPs varies considerably; some RBPs are highly selective for certain RNA sites, others bind degenerate sites, and yet other RBPs interact with RNAs broadly, with little sequence discrimination8,9,10,11,12,13,14. Defining the molecular mechanisms through which RBPs acquire ...
of age, the TEC compartment exhibited signs of functional deterioration. At this time, mature cTECs and mTECs made up only a small fraction of the thymic epithelia; by contrast, an unusually large number of cells simultaneously exhibited signatures of both progenitor types. These features suggest...