aAdvantages of using stem cells for a cell transplant rather than autologous chondrocytes include: (1) one less knee surgery, (2) decreased donor-site morbidity and (3) higher cost effectiveness, while yielding equal or better long term outcomes 使用干细胞的好处为细胞移植而不是autologous chondrocy...
Other EVs can reduce inflammation in the body and be used in the treatment of inflammatory diseases. Mesenchymal stem cells (MSCs) and some plant-derived EVs have anti-inflammatory, anti-oxidative, and immune-regulating capabilities. Also, probiotic-derived EVs can protect the intestinal microenvironm...
When both MDCK sublines were cultured in three-dimensional (3D) collagen matrices, they formed polarized hollowed spheres (Fig.2a). When treated with TGFβ, only MDCK-NBL2 cells displayed frequent protrusive events (Fig.2a), concomitant with the loss of epithelial and the gain of mesenchymal m...
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes in chromosomes. CIN arises from errors in DNA r...
Production in a plant cell culture system conveys potential advantages, such as the inability to be contaminated with or propagate mammalian pathogens, along with a potential lower cost [9], [10], [11], [12]. In the taliglucerase alfa clinical development program, the phase 1 study was ...
However, IDplex() efficacy was somewhat lower than that of Identifiler Plus when only the most informative loci (D2S1338, D21S11, D18S51 and FGA) were considered. Therefore, although each system had some particular advantages and disadvantages, overall both STR multiplexes showed similar ...
Further, F-MMA repair increased MMPE in knee extension, unlike TSS repair. These findings suggest that TSS might have more advantages for load distribution when standing or walking. 展开 关键词: knee medial meniscus magnetic resonance imaging DOI: 10.1177/23094990211049569 年份: 2021 ...
Hence, more effective OVs must be found for the treatment of MGs. Vaccinia virus (VV) is a double-stranded, enveloped, lytic DNA virus with a large capacity for foreign DNA. It has several advantages over other OVs, as it is easy to manipulate genetically, replication and spread are rapid...
EVOLUTION One beats two It makes sense to have spares of those things you might need to change at a moment's notice (such as tyres, light bulbs and fuses) but the evolutionary advantages of having two sets of chromosomes — diploidy — are less obvious. Now the experimental work in yeast...
42. It is because of this reason, NIH3T3 cells are widely used to study proteins that can trigger a gain in invasive properties43. The rationale for using NIH3T3 in the above assays is further strengthened by the fact that they are highly transfectable (~80% transfection efficiency with ...