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The 5-HT1Aagonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (1 mg/kg, i.p.) significantly reduced both the HTR and locomotor activity induced by DOM in mice. Additionally, pretreatment with the Gαi/oinhibitor PTX (0.25 µg/mouse, i.c.v.) enhanced the HTR induced by ...