6A). In accord, we found genes that are canonical markers for various cell types are generally localized to nonLADs and highly expressed in the given cell type, although some reside in T2-LADs but are still highly expressed (Fig. 6B). Combined with the observation that these loci are not...
We designated the HMM states as Type 1 LADs (T1-LADs), Type 2 LADs (T2-LADs), and nonLADs in descending order of LB1 occupancy (Fig.1B, C; Additional file5: Table 2). T1-LADs are slightly larger [median across cell types: 290 kilobases (kb)] than T2-LADs (median: 280 kb) ov...