It was previously reported that the polypeptide segment leading up to the LSGGQ motif appeared to have a role in sta- bilizing TMD-TMD interfaces in B-subfamily ABC transporters, and the term X-loop was introduced to account for this role26. Rather than an aromatic residue to stabilize the...
and we hypothesized that it could be the result of a myo1e/f-dependent membrane lifting away from the substrate around sites of FcR adhesions. In agreement with this hypothesis, no membrane lifting was observed near the aggregated actin adhesions in the dKO macrophages (Fig.7g, Supplementary M...
Full size image Our results further assign a key role to the segment 181-184 of ABCG2. It was previously reported that the polypeptide segment leading up to the LSGGQ motif appeared to have a role in stabilizing TMD-TMD interfaces in B-subfamily ABC transporters, and the term X-loop was...