and twist) of a chromophore in the excited state are directly in association with energy transformation processes, and our previous researches about aggregation-induced emission (AIE) suggest that manipulation of the excited-state intramolecular motion could tune the fluorescence property in a highly eff...
A common feature of TTFL proteins, particularly those in the negative arm, is that the proteins are enriched for Intrinsically Disordered Regions (IDRs)5. IDRs are protein regions characterized by an inability to adopt a stable tertiary structure; instead, IDRs exist in a collection of interconver...
including lipogenesis, lipolysis, fatty-acid oxidation, ketogenesis, and cholesterol efflux13, and that loss of autophagy in the liver obstructs the mobilization of triglycerides into fatty acids, resulting in steatosis and an insulin-resistant state11,14. The physiological...
Accumulation of the tau protein in fibrillar intracellular aggregates is a defining feature of multiple neurodegenerative diseases collectively referred to
After the labeling reaction, the AF647 collagen gels were washed extensively in sterile PBS for 2–3 days at room temperature to remove excess dye and collagen incapable of forming fibrils while in a labeled state. The labeled collagen was then re-solubilized using 13 mM HCl and stored ...
Together, these results demonstrate that site-specific K24 ubiquitination not only determines IFITM3 turnover and steady-state distribution in lysosomes but also regulates IFITM3 dynamic trafficking to incoming virus particles. Depletion of VCP or UBXD1 Leads to Delayed Turnover and Accumulation of ...
The phenomenon of rail corrugation, double light bands, light band mutation, and rail fatigue cracks appeared on the right rail surfaces of the turnout in the main line, and the main line left rail and the diverging line rail surfaces were good. The state of the main line right rail ...
For hinged plates, temperature change on a hinged slab has the most significant axial force effects, followed by creep and shrinkage (maximum axial forces caused in about 3000 days after the bridge construction was completed). The influences of temperature, creep, and shrinkage on the overall brid...
Then, the total volume of solvent in the cell was adjusted to 3.00 mL through the addition of the appropriate volume of the solvent mixture. The excitation wavelengths of the samples for each experiment are described in Section 3.2 and 3.3. All the steady-state luminescence measurements were ...
Förster resonance energy transfer FRET) is a process frequently produced in organic dyes, where donor and acceptor moieties may exchange their excited-state energies, in an event that causes a fluorescence enhancement. For instance, FRET from coumarin to rhodamine moieties is observed in a novel ...