is that the proteins are enriched for Intrinsically Disordered Regions (IDRs)5. IDRs are protein regions characterized by an inability to adopt a stable tertiary structure; instead, IDRs exist in a collection of interconverting conformations6. IDRs participate in diverse regulatory pathways, are freque...
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Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective degradation of gain-of-function p53 mutants has emerged as a highly attractive therapeutic strategy to target cancer cells harboring specific p53 ...
1a). Finally, p-ERK1/2 staining in the small intestine was abundant in the transit-amplifying zone of the crypt, as recently reported15 (Supplementary Fig. 1d). This specific staining pattern was only observed in fl/fl mice, whereas p-ERK1/2 immunoreactivity in ΔIEC mice was only ...
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear m
For hinged plates, temperature change on a hinged slab has the most significant axial force effects, followed by creep and shrinkage (maximum axial forces caused in about 3000 days after the bridge construction was completed). The influences of temperature, creep, and shrinkage on the overall brid...
Before germinating on a nylon filter membrane placed on the top of ATS agar plates, seeds were sterilized with 30% (v/v) bleach containing 0.1% (v/v) Triton X-100 and vernalized at 4 °C for two days. The seedlings were then grown under continuous fluorescent light (~80 μmole ...
HeLa and RPE CRISPRi/a cells were seeded in 96-well plates and cultured for 0, 24, 48, 72 and 96 h (HeLa: 1500 cells; RPE: 2500 cells). Cell viability was measured at indicated time points. For motility assays, cells were seeded into 24-well plates with a low confluence and were...
Brown on the summit of Mount Bulbein, in the town of Donegal, located on the Inishowen Peninsula in Northern Ireland [1]. Turner [1] observed that the capsules of this specimen were more slender and curved than those of the typical Hypnum denticulatum Hedw. (=P. denticulatum (Hedw.) ...
Mouse mesangial cells (MCs) were purchased from ATCC (Manassas, VA, USA). Cells were grown in a humidified 5% CO2 incubator at 37 °C in DMEM/F-12 50/50 medium containing 5% fetal bovine serum (ATCC, Manassas, VA, USA), antibiotics, and L-glutamine (Mediatech, Inc, Manassas, VA, ...