Byline: Madeleine Brindley Health EditorWestern Mail (Cardiff, Wales)
The recent identification of a fusion of fibronectin and fibroblast growth factor receptor 1 (FGFR1) as a molecular driver in some tumours not only sheds light on the pathophysiology of TIO but also opens the door to a better understanding of the transcription, translocation, post-translational ...
injected gel fibres through cerebrospinal fluid can be remotely controlled under a magnetic field and fluoroscopically tracked, and that a drug encapsulated in the gels can be released on demand under magnetic control, as we show for the delivery of doxorubicin to intracranial tumours in the mini...
FBs make up the majority of the tumor stroma (30–60%), depending on the tumor; however, the proportion of differentiated CAFs that make up the stroma is not well known35,36. While the tumor-stroma ratio depends on the patient and tumor, when a majority of the tumor is stromal, ...
Bone metastases are frequently found in the spine, ribs, pelvis, proximal femur, and skull. Bone deterioration in these areas lead to serious complications such as pain, fractures, hypercalcaemia, spinal cord compression, and other nerve compression events, which significantly reduce quality of life...
The first one includes pyrophosphate-resembling bisphosphonates, such as clodronate and etidronate, which are metabolically incorporated into nonhydrolyzable adenospine tri-phosphate (ATP) analogues that act as inhibitors of ATP-dependent enzymes. The second class which is more recent and potent includes ...
A second course of rituximab was given to 48% of the patients on an average of 9 months after initial therapy, with the median DAS28 score declining further to 3.49 (0.1-5.74). Safety and tolerability assessment of the 81 patients indicates rituximab to be well tolerated. CONCLUSIONS: ...
After a single positioning, the system allows whole-body imaging with a total field of view of 205 cm. Coils used were head-, neck-, body-, customised extremity and integrated spine coil. The patients were imaged from head to the proximal calves with STIR- and T1-weighted sequences at ...
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The underlying cause of the increased RANKL expression by stromal cells is unknown, however, this phenomenon is reduced after elimination of the giant cells [32]. Conversely, giant cells are clearly dependent on RANKL signalling by stromal cells [32, 36]. Thus, it is possible that GCTB promot...