Glioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prognosis in humans despite current treatment options. Here, we present magnetic resonance imaging (MRI) data regarding the regression of aggressive rat F98 gliomas and human U87 glioma xenografts after treatment with ...
(Nelson's syndrome). Adrenal rest tumors closely resembleLeydig celladenomas, but adrenal rest tumors are bilateral, whereasLeydig cell tumorsare usually unilateral. Adequateglucocorticoidsubstitution causes regression of the adrenal rests in 75% of cases. The tumors are always benign, and ...
Klement G, Baruchel S, Rak J, Man S, Clark K, Hickli, DJ, Bohlen P, Kerbel RS (2000) Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. Clin Invest 105: R15–R24 CAS Google Scholar Bello L, Carrabba G,...
Pearson’s correlation coefficient squared (top: r2 = 0.53, bottom: r2 = 0.3) and associated P value (top: P = 8.74 × 10−5, bottom: P = 6.34 × 10−3) are shown. Dashed line indicates linear regression model of the data. Source data Extended ...
High-grade glioma is one of the deadliest primary tumors of the central nervous system. Despite the many novel immunotherapies currently in development, it has been difficult to achieve breakthrough results in clinical studies. The reason may be due to t
Clinical tumor regression (complete response: 1/23; partial response 9/23) • Melanoma 6 NCT02354690 • Tumor-associated antigen • BRAF kinase • Biologicals: TIL, IL-2 • Drugs: Lymphodepleting chemotherapy, Vemurafenib • Adverse events (Grade 1–2: 89; Grade 3–4: 35) • Tu...
Location uncertaintyGlioma is mutated from gluey cells which surround nerve cells. Due to the wide spatial distribution of gluey cells, either High-Grade Glioma (HGG) or Low-Grade Glioma (LGG) may appear at any location inside the brain. ...
Additionally, multiple Cox regression analysis was performed to test the independent prognostic effect of TILs on outcome after adjusting for well-established prognostic factors. The assumption of proportional hazards was tested and validated by evaluating the log(-log(survival)) versus log of survival ...
P-value was calculated using F-test for linear regression. j RARRES2 gene expression in breast cancer patients14 stratified by grade, high grade = grade 3, n = 21; low-grade = grade 1 and 2, n = 10 patients. P-value was calculated using two-sided students’ t ...
Through the precise lens of univariate cox regression analysis, this list was refined to 56 genes with pronounced prognostic implications, as depicted in Fig. 2A. The expression profiles of these genes, when applied to the LUAD patient samples from the TCGA cohort, directed us towards consensus ...