Notably, cAMP has paradoxical effects on tumorigenesis, depending on the cancer types, stages and other contexts. Thus, both the antagonists and agonists of cAMP signaling can be exploited for cancer treatment. Although the structure of PKA catalytic subunit has been solved more than 30 years ago ...
* Ewing Sarcoma MRI of the entire bone should be ordered to evaluate the full extent of the lesion, which typically extends beyond the abnormality apparent on plain films 平片. MRI also is useful to evaluate the extent of the soft tissue mass, which often is very large. * * * * * ...
Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeutic approaches against solid tumors. In this line, the effects of mechanical forces on CSCs such as epithelial-mesenchymal transition, cellular plasticity, etc., the metabolism pathways of CSCs...
Xenograft models may be divided into three types; however, this is dependent on the tumor cells chosen for transplantation (cell line-derived or tumor tissue) as well as the location of transplantation (skin or an organ). The three types of xenograft models are the subcutaneoustumor xenograftmod...
This reference is an elegant demonstration that hyperploid cancer cells are under preferential immunosurveillance, as compared to their euploid counterparts, reflecting, at least in part, constitutive CALR exposure on the membrane. Article CAS PubMed Google Scholar Acebes-Huerta, A. et al. Drug-...
The Findings on Bone Scintigraphy in Patients With Suspected Tumor-Induced Osteomalacia Should Not Be Overlookedbone scintigraphybone painhypophosphatemiatumor-induced osteomalacia (TIO)Purpose Tumor-induced osteomalacia (TIO) is a chronic, devastating disease. The causative tumor is usually a small benign ...
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The effectiveness of methotrexate eluted from polymethylmethacrylate on cell lines established from giant cell tumor of bone was investigated in vitro to determine the possible efficacy of this treatment. Elation of methotrexate from polymethylmethacrylate beads and boluses was shown in vitro to be dose...
Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. J Bone Miner Res 2011; 26: 1252–1260. CAS PubMed Google Scholar Ruan J, Luo M, Wang C, Fan L, Yang SN, Cardenas M et al. Imatinib disrupts lymphoma angiogenesis by ...