Waldenstrm's macroglobulinemia (WM) is a lymphoplasmacytic lymphoma characterized by the secretion of monoclonal immunoglobulin IgM. The bone marrow (BM) is always involved and infiltrated by the...doi:10.1007/978-3-319-22584-5_7Efstathios Kastritis...
[67]. Macrophages may have both pro- and anti-tumor activities. TAMs are educated by thetumor microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumorcell motility. They are able to produce a variety ofMMPsincludingMMP1, 2, 7, 9 and 12...
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeuti...
Progression of multiple myeloma (MM) is largely dependent on the bone marrow (BM) microenvironment wherein communication through different factors including extracellular vesicles takes place. This cross-talk not only leads to drug resistance but also to the development of osteolysis. Targeting vesicle...
Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis. Background: The prognostic significance of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients at the time of primary diagn...
Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by circulating tum
the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence ...
In the World Health Organization Classification of Head and Neck Tumors 4th Edition,3 EMC is defined as “a malignant salivary gland tumor composed of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells.” From: Surgical Pathology Clinics, 2021 ...
Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study, using a mouse lymphoma model, we showed that the lymphoma resident MSCs (L-MSCs) are able to confer tumor-promoting property ...
Cancers are heterogeneous multifactorial diseases consisting of a major public health issue worldwide. Sex disparities are evidenced in cancer incidence, mortality, expression of prognosis factor, response to treatment, and survival. For both sexes, an i