The extent of each cluster indicates a highly heterogeneous level of activation, and the inclusion of a fraction near the origin indicates cells that appear to be unresponsive. Whether this is a kinetic effect or the result of the cells being in an activation-resistant state is still under ...
those manually encoded CARs can confer novel phenotypes on T cells. Due to the huge size and complexity of the combinatorial space, ML is proper to decode the combinatorial grammar of CAR and guide the design of non-natural co-stimulatory domains with improved phenotypes. Based on 13 signal mo...
The description of the boundary-layer flow, based upon a triple-deck structure, shows how the presence of the hump generates an interaction between the inviscid region just outside the layer and the viscous region near the hump. The pressure force dominant in the boundary layer and the ...
those manually encoded CARs can confer novel phenotypes on T cells. Due to the huge size and complexity of the combinatorial space, ML is proper to decode the combinatorial grammar of CAR and guide the design of non-natural co-stimulatory domains with improved phenotypes. Based on 13 signal mo...
Also, near-cognate start codons may be partially or completely located outside the original ORF of the mRNA and thus the aORF may contain 3′ or 5′ untranslated regions (UTRs) [122,123]. An extensive study on the translatome of mouse embryonic stem cells found that most non-cognate ...
Cancer-associated fibroblasts (CAFs) are located near TAMs, jointly forming the physical barrier around tumor cells that hinders immune cell and therapeutic agent access [33]. Additionally, TAMs and CAFs mutually stimulate each other’s functions, promoting immunosuppression and fibrosis [34,35]. ...
ATX can be stored in platelet α-particles. Platelet-derived lysophosphatidylcholine degrades LPA [9]. β3 integrin may bind ATX on the surface of cancer cells/platelets, providing a mechanism for the production of LPA near its receptor, thus enhancing the spread of cancer cells [119]. The ...
Chromatin interactions occur across a structural breakpoint between accessible loci near highly-expressed genes such as DNTTIP2. (b) Chromatin interaction density map of the amp1 assembly. Arrows indicate putative enhancer rewiring events, or chromatin loops which span a breakpoint on the amp1 ...
Photothermal therapy (PTT) is to induce rapid heating in tumors via gold–silica nanoshells (AuNS) mediator, which are loaded into NR8383 macrophages for delivery to the tumor site and absorbs near-infrared light to produce a therapeutic effect100,101. Photodynamic therapy (PDT) has been ...
MemBright: a family of red to near-infrared fluorescent membrane probes for advanced cellular imaging and neuroscience Cell Chem. Biol., 26 (2019), 10.1016/j.chembiol.2019.01.009 Google Scholar Colombo et al., 2013 M. Colombo, C. Moita, G. van Niel, J. Kowal, J. Vigneron, P. Benaroc...