Rosette-forming glioneuronal tumors (RGNT) of the fourth ventricle are slow-growing tumors that primarily involve the fourth ventricular region. We here report the first patient, an 8-year-old girl, with an RGNT originating in the hypothalamus and manifesting with precocious puberty. After partial...
hypothalamic releasing hormone, releasing factor, releasing hormone, RH - any of several hormones produced in the hypothalamus and carried by a vein to the anterior pituitary gland where they stimulate the release of anterior pituitary hormones; each of these hormones causes the anterior pituitary to...
We previously reported that the human melanoma cell line, SEKI, induces severe weight loss in nude mice. In the present study, we examined the expression of weight-regulating neuropeptide mRNAs in the hypothalamus of this cancer cachectic model by using a sensitive quantitative reverse transcriptase-...
Finally, immune-excluded tumors show a distinctive T-cell immune context [25]. CD8+T cells are located in the vicinity of the tumor parenchyma but are incapable of penetrating and having direct dialogue with tumor cells. Instead, immune cells circumferentially “stuck” in the peritumoral fibrobl...
2016, Progress in Lipid Research Citation Excerpt : CTRP4 and CTRP13 both suppress food intake by decreasing the expression of orexigenic neuropeptide genes in the hypothalamus [41,42]. CTRP5 protects myocytes against apoptosis by reducing palmitate-induced DNA fragmentation [43]. CTRP6 attenuates ...
An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization. Proc. Natl Acad. Sci. USA 76, 5674–5678 (1979). Article CAS PubMed PubMed Central Google Scholar Maciag, T., Mehlman, T., Friesel, R. & Schreiber, A. B. Heparin binds endothelial ...
The hypothalamus and pituitary are known to play key roles in reproductive function. A growing body of evidence indicates that environmental toxicants can alter female reproductive function by disrupting hypothalamic control of the pitui... MJP Fraites,TE Stoker,JM Goldman,... - Comprehensive Toxicol...
Chronic stress regulates the tumor microenvironment through the neuroendocrine system. The nervous system is composed of cranial and spinal nerves. Under chronic stress, the hypothalamus releases CRH, which triggers ACTH secretion from pituitary to stimulate the secretion of glucocorticoids from the adrenal...
In this review, we provide knowledge of these cancers with frequent perineural invasion. We discuss nerve fiber crosstalk with the main different components of the tumor microenvironment (TME), the immune cells, and the fibroblasts. Also, we discuss the crosstalk between the nerve fibers and the ...
regulating the immune system and influencing themicrobiota[20]. In particular, the VN has anti-inflammatory properties through its afferent [activation of the hypothalamus-pituitary-adrenocortical (HPA) axis] and efferent [activation of thecholinergicanti-inflammatory pathway (CAP)] fibers, a property ...