In subject area: Medicine and Dentistry Primary mediastinal lymphoma is a type of solid neoplasm that originates in lymphocytes usually in lymphoid tissue contained within the mediastinum. From: Medical Management of the Thoracic Surgery Patient, 2010 ...
“New treatment options are urgently needed in melanoma and other solid tumors, and the potential to improve outcomes and patient experience is very exciting. KSQ-001EX exhibited considerable efficacy in preclinical studies,” said Rodabe Amaria, MD, professor of melanoma medical oncology at MD And...
5, colon cancer is caused by colonic epithelial cells that line the lumen of the organ, which self-renew every five days from a population of stem cells located at the base of crypts in colonic epithelial cells [81]. Colon cancer is the end result of a multi-step colon tumor process ...
The internal heterogeneity of breast cancer, notably the tumor microenvironment (TME) consisting of malignant and non-malignant cells, has been extensively explored in recent years. The cells in this complex cellular ecosystem activate or suppress tumor
Because cancers can differ so greatly in severity and aggressiveness, there needs to be different treatments available. Let's take a look at two common types of treatment for malignant tumors: surgical and medical treatments. Surgery Medical Treatments Lesson Summary Register to view this lesson Are...
Transcriptional heterogeneity of tumor-associated macrophages (TAMs) has been investigated in individual cancers, but the extent to which these states transcend tumor types and represent a general feature of cancer remains unclear. We performed pan-cancer single-cell RNA sequencing analysis across nine ...
were termed to be “alternative activation,” and the ones activated by IFN-γ and/or LPS were termed to be “classical activation” [61]. Mill et al. proposed the terminology M1 for classical activated macrophages, and M2 for alternative activated macrophages in 2000 [62]. M2 was further ...
Radiologic assessments were done locally by investigators using Response Evaluation Criteria in Solid Tumors, version 1.1. Adverse events were graded according to the Common Terminology Criteria for Adverse Events, version 4.0. Outcomes The primary end point was PFS, defined as the time from randomizati...
Sections 3.1–3.3 in this chapter deal with epidemiological aspects of tumors, and how the members of the medical profession are involved in providing the data. Emphasis is given to how data on the incidences and mortalities for the different types of tumors are gathered. Section 3.4 gives an...
Alberto G. Ayala, in Urologic Surgical Pathology (Fourth Edition), 2020 Penis Normal Anatomy and Histology The penis consists of three portions: the root, the body, and the glans. The root lies in the superficial perineal pouch and provides fixation and stability. The body constitutes the ...