Seki Y, Koike T, Yano M, Aoki S, Hirasuka M, Fuse I, Aizawa Y (2002) Bone marrow necrosis with dyspnea in a patient with malignant lymphoma and plasma level of thrombomodulin, tumor necrosis factor-α, and d -dimer. Am J Hematol 70:250–253...
In bone marrow malignancies meanwhile, cell niches are disrupted and co-opted for pathogenesis. Malignancies that begin in the bone marrow can be divided into: (i) blood cancers that develop from the blood-forming cells of the marrow [6–8], and (ii) primary bone cancers, commonly known ...
The most common primary malignant bone tumor is OS. OS often originates in regions of bone growth and development, which have unique mechanisms of bone cell differentiation [41]. During OS development, the bone microenvironment often becomes imbalanced, leading to abnormal bone remodeling processes t...
The specific symptoms of a brain tumor depend on its size and location. They can be caused by several factors, including: increased pressure in the skull damage to vital tissue swelling and fluid buildup hydrocephalus, sometimes called "water on the brain," which results when the flow of cere...
Contemporary findings in the domain of cancer biology have shed light on the molecular aspects of this intricate process. Tumor cells undergoing invasion engage with other cellular entities and proteins en route to their destination. Insights into these engagements have enhanced our comprehension of the...
In this syndrome, the lymphocytes release cytokines, resulting in a systemic inflammatory response with symptoms similar to those of a severe infection [24]. Similarly, when tumor cells are being attacked by lymphocytes, the tumor cells release breakdown products while dying, which may increase ...
Bone marrow stromal antigen 2 (BST2) is a transmembrane glycoprotein and plays an essential role in innate immunity. Here we firstly found that BST2 expression was significantly elevated in hepatocellular carcinoma (HCC) tissues. High BST2 was closely related to the larger tumor size and more ...
In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong regulation of cancer development and progression by the inflammation which orchestrates the tumor microenvironment. Immune cells, residents or recruited, in the inflammation milieu can have rather contrasting effects during...
The first phase is the proliferation of immature myeloid cells (IMCs) with inhibited differentiation function in the bone marrow, mainly mediated by tumor-derived cytokines, such as IL-6, IL-11, IL-17A, granulocyte–macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating ...
Half of the six patients treated had improved neurological symptoms and negative CSF cytology. After 20 months, one of the six patients showed a complete response, with no evidence of disease. In a more recent study, autologous natural killer (NK) cells were administered intracerebroventric...