Deep learning, a subset of machine learning, has revolutionized the field of medical image analysis, offering substantial improvements in detecting and classifying various diseases [3]. In brain tumor detection, deep learning algorithms can analyze complex MRI data, identify patterns imperceptible to the...
Full size image In particular, our analysis revealed clusters of epithelial cells with transcriptional profiles unique for the tumor context. This included luminal- and basal-like cells as well as a small but distinct cancer stem cell (CSC)-like population in which Wnt-specific genes were activate...
Cell–cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell–cell communications in the ccR
Image gray values were normalized by linearly mapping the 2nd and 98th gray value percentiles, computed within a liver mask, to 0 and 1 without clipping values outside this interval. All pre-processing was performed in MeVisLab14 (MeVis Medical Solutions, Germany). The extracted patches (see ...
Metastatic colonization is one of the critical steps in tumor metastasis. A pre-metastatic niche is required for metastatic colonization and is determined by tumor-stroma interactions, yet the mechanistic underpinnings remain incompletely understood. PCR
In matched patient-derived xenografts (PDX) models, homologous TILs efficiently reduced tumor size (p < 0.0001) and underwent IL-2 absence in vivo. In the clinical section, all enrolled patients received TIL infusion using a modified TIL therapy regimen successfully with a manageable safety ...
Hello. Today we're going to resect an intraventricular tumor - that's a 49-year-old patient. And you can here see the tumor in the T1 image over here in this area and in the T2 image over there, and you can see the lesion here entering the third ventricle and potentially compressing...
Full size image All cases were received in the form of multiple pieces ranging from 1.0 cm to 11 cm in aggregate. Mean and median size was 4.6 cm and 4 cm, respectively. On histological examination, all cases demonstrated a multinodular growth pattern (Fig. 2A, B), and the specific gl...
Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. CSCs are enriched near macrophages, particularly near ...
Full size image Two points in our evolving understanding of PPB set the stage for the subsequent recognition of a tumor predisposition syndrome: one was the report from the IPPBR of 45 patients with PPB that revealed that 12 (27%) children had first and second degree relatives with other con...