TIMER (Tumor Immune Estimation Resource)数据库也是用高通量测序(RNA-Seq表达谱)数据分析肿瘤组织中免疫细胞的浸润情况,主要提供B cells, CD4+ T cells, CD8+ T cells, Neutrphils, Macrophages and Dendritic cells等六种免疫细胞的浸润情况。界面友好,简单易学又方便。网址:https://cistrome.shinyapps.io/timer/...
Importantly, more accurate estimation on cancer cells partly contributes to better estimation on the relative abundance of immune cells. We validated results by using in silico pooled bulk tumor samples, and also showed that single-cell-derived signatures provides the ability to separate T cell ...
In addition, different immune cell types play different roles in tumor control and response to therapy through either pro- or anti-tumorigenic functions. Therefore, a deep understanding of the patient-specific tumor-infiltrating immune signatures and their functions in the tumor microenvironment (TME) ...
The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment. However, the cancer treatment response is often characterized by in vitro assays or bulk transcriptomes that neglect the he...
The infiltration score of various immune cells and stroma cells within the tumor microenvironment for low-KLK8 and high-KLK8 patient groups were calculated by XCELL, CIBERSORT, EPIC, and MCP-counter algorithm based on the transcriptome data of the TCGA LUSC dataset (Supplementary Data1). The hea...
et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 8, 403–416 (2018). CAS PubMed PubMed Central Google Scholar Nejman, D. et al. The human tumor microbiome is composed of tumor type–specific intracellular ...
Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data fGSEA: Fast pre-ranked gene set enrichment analysis fl: Floxed FFPE: Formalin-fixed paraffin-embedded FWHM: Full width at half maximum GP130: Glycoprotein 130 kDa = IL6ST GO-BP: Gene Ontology ...
MDA-MB-231 breast cancer cells, much like immune cells, demonstrate a preference for low resistance channels [50]. Using trifurcating Ψ-like microchannels, the Konstantopoulos lab studied how tumor cells respond to channels with different resistances. Their research revealed that the branch channel...
The estimation is validated to verify the correctness of the model using the experimental data for the tumor growth. Second, numerical experiments are performed using a set of human data. Results show the mutual relations between tumor cells, and body immune cells in the absence and in the ...
The evaluation of breast cancer immune microenvironment has been increasingly used in clinical practice, either by counting tumor infiltrating lymphocytes or assessing programmed death ligand 1 expression. However, the spatiotemporal organization of anti-breast cancer immune response has yet to be fully ex...